DegronMD

Uniprot ID: Q6ZTA4

Source protein: Tripartite motif-containing protein 67

Source gene: TRIM67

Class: LIG_APCC_ABBAyCdc20_2

Location: 101:107

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9916

ASA_SCORE: 81.8143

COIL: 0.6501

CONS_SCORE: 0.4743

DSS_SCORE: 0.46

HELIX: 0.2193

FCONS_SCORE: 1.3116

RIG_SCORE: 0.7503

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A92V	TCGA-CK-6746	COAD	TCGA	KLSLYSE	LIG_APCC_ABBAyCdc20_2	0.0833
p.A92V	DO7938	COAD	ICGC	KLSLYSE	LIG_APCC_ABBAyCdc20_2	0.0833
p.A99T	SIDM00949	T-Cell Non-Hodgkin's Lymphoma	GDSC	KLSLYSE	LIG_APCC_ABBAyCdc20_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZTA4	Tripartite motif-containing protein 67	LIG_APCC_ABBAyCdc20_2	101:107	KLSLYSE	APC,CDC20,FZR1	0.9916	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons