DegronMD - Q6ZTA4(TRIM67)

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GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A92V	TCGA-CK-6746	COAD	TCGA	LSLYSE	LIG_APCC_ABBA_1	102:107	Mutation rewiring degron network	0.0556
p.A92V	TCGA-CK-6746	COAD	TCGA	KLSLYSE	LIG_APCC_ABBAyCdc20_2	101:107	Mutation rewiring degron network	0.0833
p.A92V	DO7938	COAD	ICGC	LSLYSE	LIG_APCC_ABBA_1	102:107	Mutation rewiring degron network	0.0556
p.A92V	DO7938	COAD	ICGC	KLSLYSE	LIG_APCC_ABBAyCdc20_2	101:107	Mutation rewiring degron network	0.0833
p.G111D	DO222494	MELA	ICGC	DSGYGS	DEG_SCF_TRCP1_1	109:114	Mutation altering degron motif	0.7198
p.S110C	DO229151	THCA	ICGC	DSGYGS	DEG_SCF_TRCP1_1	109:114	Mutation altering degron motif	0.7541
p.A99T	SIDM00949	T-Cell Non-Hodgkin's Lymphoma	GDSC	DSGYGS	DEG_SCF_TRCP1_1	109:114	Mutation rewiring degron network	0.0556
p.A99T	SIDM00949	T-Cell Non-Hodgkin's Lymphoma	GDSC	LSLYSE	LIG_APCC_ABBA_1	102:107	Mutation rewiring degron network	0.25
p.A99T	SIDM00949	T-Cell Non-Hodgkin's Lymphoma	GDSC	KLSLYSE	LIG_APCC_ABBAyCdc20_2	101:107	Mutation rewiring degron network	0.2778
p.P120L	HCC1954	breast	COSMIC	DSGYGS	DEG_SCF_TRCP1_1	109:114	Mutation substituting flanking lysine	0.2778

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons