DegronMD

Uniprot ID: Q6ZTA4

Source protein: Tripartite motif-containing protein 67

Source gene: TRIM67

Class: LIG_APCC_ABBA_1

Location: 102:107

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9942

ASA_SCORE: 78.2667

COIL: 0.6375

CONS_SCORE: 0.4754

DSS_SCORE: 0.4539

HELIX: 0.217

FCONS_SCORE: 1.2856

RIG_SCORE: 0.7477

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A92V	TCGA-CK-6746	COAD	TCGA	LSLYSE	LIG_APCC_ABBA_1	0.0556
p.A92V	DO7938	COAD	ICGC	LSLYSE	LIG_APCC_ABBA_1	0.0556
p.A99T	SIDM00949	T-Cell Non-Hodgkin's Lymphoma	GDSC	LSLYSE	LIG_APCC_ABBA_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZTA4	Tripartite motif-containing protein 67	LIG_APCC_ABBA_1	102:107	LSLYSE	APC,CDC20,FZR1	0.9942	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons