DegronMD

Uniprot ID: Q7Z6E9

Source protein: E3 ubiquitin-protein ligase RBBP6

Source gene: RBBP6

Class: DEG_SCF_SKP2-CKS1_1

Location: 1190:1197

E3 ligase: SKP2,CSK1

DEGRON score: 0.9933

ASA_SCORE: 107.6375

COIL: 0.7441

CONS_SCORE: 0.329

DSS_SCORE: 0.6809

HELIX: 0.2478

FCONS_SCORE: 1.0821

RIG_SCORE: 0.6932

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1182C	TCGA-06-5416	GBM	TCGA	KMDRTPEK	DEG_SCF_SKP2-CKS1_1	0.1111
p.R1182C	DO10880	GBM	ICGC	KMDRTPEK	DEG_SCF_SKP2-CKS1_1	0.1111
p.A1204V	TCGA-AG-3892	READ	TCGA	KMDRTPEK	DEG_SCF_SKP2-CKS1_1	0.1389
p.A1204V	TCGA-IB-7651	PAAD	TCGA	KMDRTPEK	DEG_SCF_SKP2-CKS1_1	0.1389
p.A1204V	DO46657	PAAD	ICGC	KMDRTPEK	DEG_SCF_SKP2-CKS1_1	0.1389
p.A1204V	DO36394	READ	ICGC	KMDRTPEK	DEG_SCF_SKP2-CKS1_1	0.1389
p.A1204V	SIDM01617	Endometrial Carcinoma	GDSC	KMDRTPEK	DEG_SCF_SKP2-CKS1_1	0.1389
p.A1204V	ACH-000994	Endometrial/Uterine Cancer	CCLE	KMDRTPEK	DEG_SCF_SKP2-CKS1_1	0.1389
p.K1199T	TCGA-AJ-A3EL	UCEC	TCGA	KMDRTPEK	DEG_SCF_SKP2-CKS1_1	0.2778
p.K1199T	DO41542	UCEC	ICGC	KMDRTPEK	DEG_SCF_SKP2-CKS1_1	0.2778
p.P1180A	TCGA-B0-4698	KIRC	TCGA	KMDRTPEK	DEG_SCF_SKP2-CKS1_1	0.0556
p.P1180A	DO20368	KIRC	ICGC	KMDRTPEK	DEG_SCF_SKP2-CKS1_1	0.0556
p.S1201Y	TCGA-EY-A1GI	UCEC	TCGA	KMDRTPEK	DEG_SCF_SKP2-CKS1_1	0.2222
p.S1201Y	TCGA-F5-6814	READ	TCGA	KMDRTPEK	DEG_SCF_SKP2-CKS1_1	0.2222
p.S1201Y	DO36556	READ	ICGC	KMDRTPEK	DEG_SCF_SKP2-CKS1_1	0.2222
p.S1201Y	DO41211	UCEC	ICGC	KMDRTPEK	DEG_SCF_SKP2-CKS1_1	0.2222
p.R1182H	TCGA-FI-A2D5	UCEC	TCGA	KMDRTPEK	DEG_SCF_SKP2-CKS1_1	0.1111
p.R1182H	DO41331	UCEC	ICGC	KMDRTPEK	DEG_SCF_SKP2-CKS1_1	0.1111
p.R1182H	SIDM00529	Breast Carcinoma	GDSC	KMDRTPEK	DEG_SCF_SKP2-CKS1_1	0.1111
p.R1182H	SIDM00068	Colorectal Carcinoma	GDSC	KMDRTPEK	DEG_SCF_SKP2-CKS1_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z6E9	E3 ubiquitin-protein ligase RBBP6	DEG_SCF_SKP2-CKS1_1	1190:1197	KMDRTPEK	SKP2,CSK1	0.9933	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons