DegronMD

Uniprot ID: P15498

Source protein: Proto-oncogene vav

Source gene: VAV1

Class: LIG_APCC_ABBAyCdc20_2

Location: 596:602

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6439

ASA_SCORE: 73.7571

COIL: 0.4623

CONS_SCORE: 0.2666

DSS_SCORE: 0.4029

HELIX: 0.0663

FCONS_SCORE: 0.8035

RIG_SCORE: 0.8019

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G605W	TCGA-19-1788	GBM	TCGA	KMEVFQE	LIG_APCC_ABBAyCdc20_2	0.25
p.G605W	DO12712	GBM	ICGC	KMEVFQE	LIG_APCC_ABBAyCdc20_2	0.25
p.G605R	TCGA-A6-3809	COAD	TCGA	KMEVFQE	LIG_APCC_ABBAyCdc20_2	0.25
p.G605R	DO8722	COAD	ICGC	KMEVFQE	LIG_APCC_ABBAyCdc20_2	0.25
p.G611E	TCGA-FR-A729	SKCM	TCGA	KMEVFQE	LIG_APCC_ABBAyCdc20_2	0.0833
p.G611E	DO48618	SKCM	ICGC	KMEVFQE	LIG_APCC_ABBAyCdc20_2	0.0833
p.P596A	DO219049	BLCA	ICGC	KMEVFQE	LIG_APCC_ABBAyCdc20_2	0.7503
p.T587K	DO10880	GBM	ICGC	KMEVFQE	LIG_APCC_ABBAyCdc20_2	0.1944
p.G593V	DO229029	LICA	ICGC	KMEVFQE	LIG_APCC_ABBAyCdc20_2	0.25
p.G593V	DO229009	LICA	ICGC	KMEVFQE	LIG_APCC_ABBAyCdc20_2	0.25
p.G593V	DO51510	PACA	ICGC	KMEVFQE	LIG_APCC_ABBAyCdc20_2	0.25
p.K596N	DO229027	LICA	ICGC	KMEVFQE	LIG_APCC_ABBAyCdc20_2	0.6918
p.K596N	ACH-001409	Bladder Cancer	CCLE	KMEVFQE	LIG_APCC_ABBAyCdc20_2	0.6918
p.G593C	DO219161	LUSC	ICGC	KMEVFQE	LIG_APCC_ABBAyCdc20_2	0.25
p.P609S	DO229502	SKCA	ICGC	KMEVFQE	LIG_APCC_ABBAyCdc20_2	0.1389
p.P596S	DO50280	SKCM	ICGC	KMEVFQE	LIG_APCC_ABBAyCdc20_2	0.6752
p.P596S	DO223907	SKCM	ICGC	KMEVFQE	LIG_APCC_ABBAyCdc20_2	0.6752
p.K601N	DO41235	UCEC	ICGC	KMEVFQE	LIG_APCC_ABBAyCdc20_2	0.6918
p.M597I	ACH-000791	Lung Cancer	CCLE	KMEVFQE	LIG_APCC_ABBAyCdc20_2	0.6507

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P15498	Proto-oncogene vav	LIG_APCC_ABBAyCdc20_2	596:602	KMEVFQE	APC,CDC20,FZR1	0.6439	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons