DegronMD - P15498(VAV1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G605W	TCGA-19-1788	GBM	TCGA	MEVFQE	LIG_APCC_ABBA_1	597:602	Mutation rewiring degron network	0.25
p.G605W	TCGA-19-1788	GBM	TCGA	KMEVFQE	LIG_APCC_ABBAyCdc20_2	596:602	Mutation rewiring degron network	0.25
p.G605W	DO12712	GBM	ICGC	MEVFQE	LIG_APCC_ABBA_1	597:602	Mutation rewiring degron network	0.25
p.G605W	DO12712	GBM	ICGC	KMEVFQE	LIG_APCC_ABBAyCdc20_2	596:602	Mutation rewiring degron network	0.25
p.G605R	TCGA-A6-3809	COAD	TCGA	MEVFQE	LIG_APCC_ABBA_1	597:602	Mutation rewiring degron network	0.25
p.G605R	TCGA-A6-3809	COAD	TCGA	KMEVFQE	LIG_APCC_ABBAyCdc20_2	596:602	Mutation rewiring degron network	0.25
p.G605R	DO8722	COAD	ICGC	MEVFQE	LIG_APCC_ABBA_1	597:602	Mutation rewiring degron network	0.25
p.G605R	DO8722	COAD	ICGC	KMEVFQE	LIG_APCC_ABBAyCdc20_2	596:602	Mutation rewiring degron network	0.25
p.G611E	TCGA-FR-A729	SKCM	TCGA	MEVFQE	LIG_APCC_ABBA_1	597:602	Mutation rewiring degron network	0.0833
p.G611E	TCGA-FR-A729	SKCM	TCGA	KMEVFQE	LIG_APCC_ABBAyCdc20_2	596:602	Mutation rewiring degron network	0.0833
p.G611E	DO48618	SKCM	ICGC	MEVFQE	LIG_APCC_ABBA_1	597:602	Mutation rewiring degron network	0.0833
p.G611E	DO48618	SKCM	ICGC	KMEVFQE	LIG_APCC_ABBAyCdc20_2	596:602	Mutation rewiring degron network	0.0833
p.P596A	DO219049	BLCA	ICGC	KMEVFQE	LIG_APCC_ABBAyCdc20_2	596:602	Mutation altering degron motif	0.7503
p.T587K	DO10880	GBM	ICGC	MEVFQE	LIG_APCC_ABBA_1	597:602	Mutation substituting flanking lysine	0.1667
p.T587K	DO10880	GBM	ICGC	KMEVFQE	LIG_APCC_ABBAyCdc20_2	596:602	Mutation substituting flanking lysine	0.1944
p.G593V	DO229029	LICA	ICGC	MEVFQE	LIG_APCC_ABBA_1	597:602	Mutation rewiring degron network	0.2222
p.G593V	DO229029	LICA	ICGC	KMEVFQE	LIG_APCC_ABBAyCdc20_2	596:602	Mutation rewiring degron network	0.25
p.G593V	DO229009	LICA	ICGC	MEVFQE	LIG_APCC_ABBA_1	597:602	Mutation rewiring degron network	0.2222
p.G593V	DO229009	LICA	ICGC	KMEVFQE	LIG_APCC_ABBAyCdc20_2	596:602	Mutation rewiring degron network	0.25
p.G593V	DO51510	PACA	ICGC	MEVFQE	LIG_APCC_ABBA_1	597:602	Mutation rewiring degron network	0.2222
p.G593V	DO51510	PACA	ICGC	KMEVFQE	LIG_APCC_ABBAyCdc20_2	596:602	Mutation rewiring degron network	0.25
p.K596N	DO229027	LICA	ICGC	KMEVFQE	LIG_APCC_ABBAyCdc20_2	596:602	Mutation altering degron motif	0.6918
p.K596N	ACH-001409	Bladder Cancer	CCLE	KMEVFQE	LIG_APCC_ABBAyCdc20_2	596:602	Mutation altering degron motif	0.6918
p.G593C	DO219161	LUSC	ICGC	MEVFQE	LIG_APCC_ABBA_1	597:602	Mutation rewiring degron network	0.2222
p.G593C	DO219161	LUSC	ICGC	KMEVFQE	LIG_APCC_ABBAyCdc20_2	596:602	Mutation rewiring degron network	0.25
p.P609S	DO229502	SKCA	ICGC	MEVFQE	LIG_APCC_ABBA_1	597:602	Mutation rewiring degron network	0.1389
p.P609S	DO229502	SKCA	ICGC	KMEVFQE	LIG_APCC_ABBAyCdc20_2	596:602	Mutation rewiring degron network	0.1389
p.P596S	DO50280	SKCM	ICGC	KMEVFQE	LIG_APCC_ABBAyCdc20_2	596:602	Mutation altering degron motif	0.6752
p.P596S	DO223907	SKCM	ICGC	KMEVFQE	LIG_APCC_ABBAyCdc20_2	596:602	Mutation altering degron motif	0.6752
p.K601N	DO41235	UCEC	ICGC	MEVFQE	LIG_APCC_ABBA_1	597:602	Mutation altering degron motif	0.6918
p.K601N	DO41235	UCEC	ICGC	KMEVFQE	LIG_APCC_ABBAyCdc20_2	596:602	Mutation altering degron motif	0.6918
p.M597I	ACH-000791	Lung Cancer	CCLE	MEVFQE	LIG_APCC_ABBA_1	597:602	Mutation altering degron motif	0.6507
p.M597I	ACH-000791	Lung Cancer	CCLE	KMEVFQE	LIG_APCC_ABBAyCdc20_2	596:602	Mutation altering degron motif	0.6507

Kaplan plot for VAV1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

VAV1

UniProt ID: P15498

Entrez ID: 7409

Protein name: Proto-oncogene vav

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for VAV1 in