DegronMD

Uniprot ID: P15498

Source protein: Proto-oncogene vav

Source gene: VAV1

Class: LIG_APCC_ABBA_1

Location: 597:602

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6161

ASA_SCORE: 68.0833

COIL: 0.4507

CONS_SCORE: 0.2645

DSS_SCORE: 0.4112

HELIX: 0.071

FCONS_SCORE: 0.7951

RIG_SCORE: 0.8107

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G605W	TCGA-19-1788	GBM	TCGA	MEVFQE	LIG_APCC_ABBA_1	0.25
p.G605W	DO12712	GBM	ICGC	MEVFQE	LIG_APCC_ABBA_1	0.25
p.G605R	TCGA-A6-3809	COAD	TCGA	MEVFQE	LIG_APCC_ABBA_1	0.25
p.G605R	DO8722	COAD	ICGC	MEVFQE	LIG_APCC_ABBA_1	0.25
p.G611E	TCGA-FR-A729	SKCM	TCGA	MEVFQE	LIG_APCC_ABBA_1	0.0833
p.G611E	DO48618	SKCM	ICGC	MEVFQE	LIG_APCC_ABBA_1	0.0833
p.T587K	DO10880	GBM	ICGC	MEVFQE	LIG_APCC_ABBA_1	0.1667
p.G593V	DO229029	LICA	ICGC	MEVFQE	LIG_APCC_ABBA_1	0.2222
p.G593V	DO229009	LICA	ICGC	MEVFQE	LIG_APCC_ABBA_1	0.2222
p.G593V	DO51510	PACA	ICGC	MEVFQE	LIG_APCC_ABBA_1	0.2222
p.G593C	DO219161	LUSC	ICGC	MEVFQE	LIG_APCC_ABBA_1	0.2222
p.P609S	DO229502	SKCA	ICGC	MEVFQE	LIG_APCC_ABBA_1	0.1389
p.K601N	DO41235	UCEC	ICGC	MEVFQE	LIG_APCC_ABBA_1	0.6918
p.M597I	ACH-000791	Lung Cancer	CCLE	MEVFQE	LIG_APCC_ABBA_1	0.6507

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P15498	Proto-oncogene vav	LIG_APCC_ABBA_1	597:602	MEVFQE	APC,CDC20,FZR1	0.6161	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons