DegronMD

Uniprot ID: Q8N2I9

Source protein: Serine/threonine-protein kinase 40

Source gene: STK40

Class: LIG_APCC_ABBAyCdc20_2

Location: 87:93

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8969

ASA_SCORE: 67.0714

COIL: 0.2581

CONS_SCORE: 0.9039

DSS_SCORE: 0.3055

HELIX: 0.7259

FCONS_SCORE: 1.2307

RIG_SCORE: 0.7904

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L97M	TCGA-AJ-A5DW	UCEC	TCGA	KMLLHTE	LIG_APCC_ABBAyCdc20_2	0.2222
p.L97M	DO50075	UCEC	ICGC	KMLLHTE	LIG_APCC_ABBAyCdc20_2	0.2222
p.Y94C	TCGA-CK-4951	COAD	TCGA	KMLLHTE	LIG_APCC_ABBAyCdc20_2	0.3056
p.Y94C	DO10582	COAD	ICGC	KMLLHTE	LIG_APCC_ABBAyCdc20_2	0.3056
p.E93K	DO233787	GACA	ICGC	KMLLHTE	LIG_APCC_ABBAyCdc20_2	0.7022
p.E93K	DO46346	OV	ICGC	KMLLHTE	LIG_APCC_ABBAyCdc20_2	0.7022
p.R89Q	SIDM01619	Endometrial Carcinoma	GDSC	KMLLHTE	LIG_APCC_ABBAyCdc20_2	0.7329
p.R84Q	ACH-000984	Endometrial/Uterine Cancer	CCLE	KMLLHTE	LIG_APCC_ABBAyCdc20_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N2I9	Serine/threonine-protein kinase 40	LIG_APCC_ABBAyCdc20_2	87:93	KMLLHTE	APC,CDC20,FZR1	0.8969	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons