DegronMD

Uniprot ID: Q9C026

Source protein: E3 ubiquitin-protein ligase TRIM9

Source gene: TRIM9

Class: LIG_APCC_ABBAyCdc20_2

Location: 67:73

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8655

ASA_SCORE: 68.1571

COIL: 0.6073

CONS_SCORE: 0.724

DSS_SCORE: 0.2953

HELIX: 0.2263

FCONS_SCORE: 1.0057

RIG_SCORE: 0.7853

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D59A	TCGA-CG-5733	STAD	TCGA	KMSLYSE	LIG_APCC_ABBAyCdc20_2	0.1111
p.D59A	DO38551	STAD	ICGC	KMSLYSE	LIG_APCC_ABBAyCdc20_2	0.1111
p.S72R	DO228978	LICA	ICGC	KMSLYSE	LIG_APCC_ABBAyCdc20_2	0.6316
p.S69R	DO229019	LICA	ICGC	KMSLYSE	LIG_APCC_ABBAyCdc20_2	0.6316
p.A74T	DO48682	LIRI	ICGC	KMSLYSE	LIG_APCC_ABBAyCdc20_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9C026	E3 ubiquitin-protein ligase TRIM9	LIG_APCC_ABBAyCdc20_2	67:73	KMSLYSE	APC,CDC20,FZR1	0.8655	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons