DegronMD - Q9C026(TRIM9)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G77C	TCGA-17-Z031	LUAD	TCGA	DSGYGS	DEG_SCF_TRCP1_1	75:80	Mutation altering degron motif	0.76
p.R35H	TCGA-96-8170	LUSC	TCGA	LVQTPESE	DEG_SCF_FBW7_2	38:45	Mutation rewiring degron network	0.25
p.R35H	DO27691	LUSC	ICGC	LVQTPESE	DEG_SCF_FBW7_2	38:45	Mutation rewiring degron network	0.25
p.D75N	TCGA-CA-6718	COAD	TCGA	DSGYGS	DEG_SCF_TRCP1_1	75:80	Mutation altering degron motif	0.6932
p.D75N	DO7801	COAD	ICGC	DSGYGS	DEG_SCF_TRCP1_1	75:80	Mutation altering degron motif	0.6932
p.D59A	TCGA-CG-5733	STAD	TCGA	MSLYSE	LIG_APCC_ABBA_1	68:73	Mutation rewiring degron network	0.0833
p.D59A	TCGA-CG-5733	STAD	TCGA	KMSLYSE	LIG_APCC_ABBAyCdc20_2	67:73	Mutation rewiring degron network	0.1111
p.D59A	DO38551	STAD	ICGC	MSLYSE	LIG_APCC_ABBA_1	68:73	Mutation rewiring degron network	0.0833
p.D59A	DO38551	STAD	ICGC	KMSLYSE	LIG_APCC_ABBAyCdc20_2	67:73	Mutation rewiring degron network	0.1111
p.A53T	TCGA-HU-A4H8	STAD	TCGA	LVQTPESE	DEG_SCF_FBW7_2	38:45	Mutation rewiring degron network	0.1111
p.A53T	DO47869	STAD	ICGC	LVQTPESE	DEG_SCF_FBW7_2	38:45	Mutation rewiring degron network	0.1111
p.S49R	TCGA-VR-A8EW	ESCA	TCGA	LVQTPESE	DEG_SCF_FBW7_2	38:45	Mutation blocking phosphorylation signal	0.6667
p.N36H	TCGA-XU-A92R	THYM	TCGA	LVQTPESE	DEG_SCF_FBW7_2	38:45	Mutation rewiring degron network	0.2778
p.A87T	DO52439	COCA	ICGC	DSGYGS	DEG_SCF_TRCP1_1	75:80	Mutation rewiring degron network	0.1389
p.R51W	DO234334	ESAD	ICGC	LVQTPESE	DEG_SCF_FBW7_2	38:45	Mutation rewiring degron network	0.1667
p.R51W	DO233866	GACA	ICGC	LVQTPESE	DEG_SCF_FBW7_2	38:45	Mutation rewiring degron network	0.1667
p.A34T	DO233888	GACA	ICGC	LVQTPESE	DEG_SCF_FBW7_2	38:45	Mutation rewiring degron network	0.2222
p.S72R	DO228978	LICA	ICGC	MSLYSE	LIG_APCC_ABBA_1	68:73	Mutation altering degron motif	0.6316
p.S72R	DO228978	LICA	ICGC	KMSLYSE	LIG_APCC_ABBAyCdc20_2	67:73	Mutation altering degron motif	0.6316
p.S69R	DO229019	LICA	ICGC	MSLYSE	LIG_APCC_ABBA_1	68:73	Mutation altering degron motif	0.6316
p.S69R	DO229019	LICA	ICGC	KMSLYSE	LIG_APCC_ABBAyCdc20_2	67:73	Mutation altering degron motif	0.6316
p.H50N	DO229038	LICA	ICGC	LVQTPESE	DEG_SCF_FBW7_2	38:45	Mutation rewiring degron network	0.1944
p.Q40K	DO229037	LICA	ICGC	LVQTPESE	DEG_SCF_FBW7_2	38:45	Mutation altering degron motif	0.5833
p.R35S	DO229045	LICA	ICGC	LVQTPESE	DEG_SCF_FBW7_2	38:45	Mutation rewiring degron network	0.25
p.A74T	DO48682	LIRI	ICGC	DSGYGS	DEG_SCF_TRCP1_1	75:80	Mutation rewiring degron network	0.3056
p.A74T	DO48682	LIRI	ICGC	MSLYSE	LIG_APCC_ABBA_1	68:73	Mutation rewiring degron network	0.3056
p.A74T	DO48682	LIRI	ICGC	KMSLYSE	LIG_APCC_ABBAyCdc20_2	67:73	Mutation rewiring degron network	0.3056
p.Y78N	DO220907	MELA	ICGC	DSGYGS	DEG_SCF_TRCP1_1	75:80	Mutation altering degron motif	0.7059
p.T90I	SIDM00216	Colorectal Carcinoma	GDSC	DSGYGS	DEG_SCF_TRCP1_1	75:80	Mutation rewiring degron network	0.0556
p.T90I	ACH-000989	Colon/Colorectal Cancer	CCLE	DSGYGS	DEG_SCF_TRCP1_1	75:80	Mutation rewiring degron network	0.0556
p.T90I	SNU-175	large intestine	COSMIC	DSGYGS	DEG_SCF_TRCP1_1	75:80	Mutation rewiring degron network	0.0556
p.Q31E	SIDM00937	Oral Cavity Carcinoma	GDSC	LVQTPESE	DEG_SCF_FBW7_2	38:45	Mutation rewiring degron network	0.1389
p.Q31E	ACH-000832	Head and Neck Cancer	CCLE	LVQTPESE	DEG_SCF_FBW7_2	38:45	Mutation rewiring degron network	0.1389
p.Q31E	CAL-27	upper aerodigestive tract	COSMIC	LVQTPESE	DEG_SCF_FBW7_2	38:45	Mutation rewiring degron network	0.1389
p.A85T	SIDM00165	Other Solid Cancers	GDSC	DSGYGS	DEG_SCF_TRCP1_1	75:80	Mutation rewiring degron network	0.1944
p.A32E	SIDM00228	Thyroid Gland Carcinoma	GDSC	LVQTPESE	DEG_SCF_FBW7_2	38:45	Mutation rewiring degron network	0.1667
p.A32E	ACH-000897	Thyroid Cancer	CCLE	LVQTPESE	DEG_SCF_FBW7_2	38:45	Mutation rewiring degron network	0.1667

Kaplan plot for TRIM9 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TRIM9

UniProt ID: Q9C026

Entrez ID: 114088

Protein name: E3 ubiquitin-protein ligase TRIM9 (EC 2.3.2.27) (RING finger protein 91) (RING-type E3 ubiquitin transferase TRIM9) (Tripartite motif-containing protein 9)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TRIM9 in