DegronMD

Uniprot ID: Q9C026

Source protein: E3 ubiquitin-protein ligase TRIM9

Source gene: TRIM9

Class: LIG_APCC_ABBA_1

Location: 68:73

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9477

ASA_SCORE: 61.2333

COIL: 0.6195

CONS_SCORE: 0.7263

DSS_SCORE: 0.2908

HELIX: 0.2085

FCONS_SCORE: 1.0084

RIG_SCORE: 0.7789

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D59A	TCGA-CG-5733	STAD	TCGA	MSLYSE	LIG_APCC_ABBA_1	0.0833
p.D59A	DO38551	STAD	ICGC	MSLYSE	LIG_APCC_ABBA_1	0.0833
p.S72R	DO228978	LICA	ICGC	MSLYSE	LIG_APCC_ABBA_1	0.6316
p.S69R	DO229019	LICA	ICGC	MSLYSE	LIG_APCC_ABBA_1	0.6316
p.A74T	DO48682	LIRI	ICGC	MSLYSE	LIG_APCC_ABBA_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9C026	E3 ubiquitin-protein ligase TRIM9	LIG_APCC_ABBA_1	68:73	MSLYSE	APC,CDC20,FZR1	0.9477	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons