DegronMD

Uniprot ID: Q9C026

Source protein: E3 ubiquitin-protein ligase TRIM9

Source gene: TRIM9

Class: DEG_SCF_TRCP1_1

Location: 75:80

E3 ligase: BTRC

DEGRON score: 0.7947

ASA_SCORE: 48.8667

COIL: 0.7007

CONS_SCORE: 0.7482

DSS_SCORE: 0.2819

HELIX: 0.0803

FCONS_SCORE: 1.0421

RIG_SCORE: 0.6597

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G77C	TCGA-17-Z031	LUAD	TCGA	DSGYGS	DEG_SCF_TRCP1_1	0.76
p.D75N	TCGA-CA-6718	COAD	TCGA	DSGYGS	DEG_SCF_TRCP1_1	0.6932
p.D75N	DO7801	COAD	ICGC	DSGYGS	DEG_SCF_TRCP1_1	0.6932
p.A87T	DO52439	COCA	ICGC	DSGYGS	DEG_SCF_TRCP1_1	0.1389
p.A74T	DO48682	LIRI	ICGC	DSGYGS	DEG_SCF_TRCP1_1	0.3056
p.Y78N	DO220907	MELA	ICGC	DSGYGS	DEG_SCF_TRCP1_1	0.7059
p.T90I	SIDM00216	Colorectal Carcinoma	GDSC	DSGYGS	DEG_SCF_TRCP1_1	0.0556
p.T90I	ACH-000989	Colon/Colorectal Cancer	CCLE	DSGYGS	DEG_SCF_TRCP1_1	0.0556
p.T90I	SNU-175	large_intestine	COSMIC	DSGYGS	DEG_SCF_TRCP1_1	0.0556
p.A85T	SIDM00165	Other Solid Cancers	GDSC	DSGYGS	DEG_SCF_TRCP1_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9C026	E3 ubiquitin-protein ligase TRIM9	DEG_SCF_TRCP1_1	75:80	DSGYGS	BTRC	0.7947	More...
Q6ZTA4	Tripartite motif-containing protein 67	DEG_SCF_TRCP1_1	109:114	DSGYGS	BTRC	0.9957	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons