DegronMD

Uniprot ID: Q9C026

Source protein: E3 ubiquitin-protein ligase TRIM9

Source gene: TRIM9

Class: DEG_SCF_FBW7_2

Location: 38:45

E3 ligase: FBXW7

DEGRON score: 0.984

ASA_SCORE: 85.575

COIL: 0.7664

CONS_SCORE: 0.7221

DSS_SCORE: 0.3601

HELIX: 0.1821

FCONS_SCORE: 0.9987

RIG_SCORE: 0.72

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S49R	TCGA-VR-A8EW	ESCA	TCGA	LVQTPESE	DEG_SCF_FBW7_2	0.6667
p.Q40K	DO229037	LICA	ICGC	LVQTPESE	DEG_SCF_FBW7_2	0.5833
p.N36H	TCGA-XU-A92R	THYM	TCGA	LVQTPESE	DEG_SCF_FBW7_2	0.2778
p.R35H	TCGA-96-8170	LUSC	TCGA	LVQTPESE	DEG_SCF_FBW7_2	0.25
p.R35H	DO27691	LUSC	ICGC	LVQTPESE	DEG_SCF_FBW7_2	0.25
p.R35S	DO229045	LICA	ICGC	LVQTPESE	DEG_SCF_FBW7_2	0.25
p.A34T	DO233888	GACA	ICGC	LVQTPESE	DEG_SCF_FBW7_2	0.2222
p.H50N	DO229038	LICA	ICGC	LVQTPESE	DEG_SCF_FBW7_2	0.1944
p.R51W	DO234334	ESAD	ICGC	LVQTPESE	DEG_SCF_FBW7_2	0.1667
p.R51W	DO233866	GACA	ICGC	LVQTPESE	DEG_SCF_FBW7_2	0.1667
p.A32E	SIDM00228	Thyroid Gland Carcinoma	GDSC	LVQTPESE	DEG_SCF_FBW7_2	0.1667
p.A32E	ACH-000897	Thyroid Cancer	CCLE	LVQTPESE	DEG_SCF_FBW7_2	0.1667
p.Q31E	SIDM00937	Oral Cavity Carcinoma	GDSC	LVQTPESE	DEG_SCF_FBW7_2	0.1389
p.Q31E	ACH-000832	Head and Neck Cancer	CCLE	LVQTPESE	DEG_SCF_FBW7_2	0.1389
p.Q31E	CAL-27	upper_aerodigestive_tract	COSMIC	LVQTPESE	DEG_SCF_FBW7_2	0.1389
p.A53T	TCGA-HU-A4H8	STAD	TCGA	LVQTPESE	DEG_SCF_FBW7_2	0.1111
p.A53T	DO47869	STAD	ICGC	LVQTPESE	DEG_SCF_FBW7_2	0.1111

Showing 1 to 17 of 17 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9C026	E3 ubiquitin-protein ligase TRIM9	DEG_SCF_FBW7_2	38:45	LVQTPESE	FBXW7	0.984	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons