DegronMD

Uniprot ID: Q53F19

Source protein: Nuclear cap-binding protein subunit 3

Source gene: NCBP3

Class: LIG_APCC_ABBAyCdc20_2

Location: 421:427

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9207

ASA_SCORE: 93.1143

COIL: 0.6093

CONS_SCORE: 0.4293

DSS_SCORE: 0.5003

HELIX: 0.2584

FCONS_SCORE: 1.0448

RIG_SCORE: 0.7732

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A426G	SIDM00959	Acute Myeloid Leukemia	GDSC	KMTMYAD	LIG_APCC_ABBAyCdc20_2	0.6429
p.A426G	CMK	haematopoietic_and_lymphoid_tissue	COSMIC	KMTMYAD	LIG_APCC_ABBAyCdc20_2	0.6429

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q53F19	Nuclear cap-binding protein subunit 3	LIG_APCC_ABBAyCdc20_2	421:427	KMTMYAD	APC,CDC20,FZR1	0.9207	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons