DegronMD - Q53F19(NCBP3)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T63M	SIDM00259	Neuroblastoma	GDSC	VRRSLKELI	DEG_APCC_DBOX_1	52:60	Mutation rewiring degron network	0.25
p.T63M	SIDM00422	Hodgkin's Lymphoma	GDSC	VRRSLKELI	DEG_APCC_DBOX_1	52:60	Mutation rewiring degron network	0.25
p.T63M	SIDM01648	Non-Cancerous	GDSC	VRRSLKELI	DEG_APCC_DBOX_1	52:60	Mutation rewiring degron network	0.25
p.A426G	SIDM00959	Acute Myeloid Leukemia	GDSC	MTMYAD	LIG_APCC_ABBA_1	422:427	Mutation altering degron motif	0.6429
p.A426G	SIDM00959	Acute Myeloid Leukemia	GDSC	KMTMYAD	LIG_APCC_ABBAyCdc20_2	421:427	Mutation altering degron motif	0.6429
p.A426G	CMK	haematopoietic and lymphoid tissue	COSMIC	MTMYAD	LIG_APCC_ABBA_1	422:427	Mutation altering degron motif	0.6429
p.A426G	CMK	haematopoietic and lymphoid tissue	COSMIC	KMTMYAD	LIG_APCC_ABBAyCdc20_2	421:427	Mutation altering degron motif	0.6429

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons