DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
KNDLYRE
Uniprot ID:
Q16560
Source protein:
U11/U12 small nuclear ribonucleoprotein 35 kDa protein
Source gene:
SNRNP35
Class:
LIG_APCC_ABBAyCdc20_2
Location:
172:178
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9525
ASA_SCORE:
118.1
COIL:
0.8364
CONS_SCORE:
0.4144
DSS_SCORE:
0.4621
HELIX:
0.1703
FCONS_SCORE:
0.8342
RIG_SCORE:
0.7754
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.E178G
ACH-001164
Sarcoma
CCLE
KNDLYRE
LIG_APCC_ABBAyCdc20_2
0.7199
p.L173M
TCGA-ER-A1A1
SKCM
TCGA
KNDLYRE
LIG_APCC_ABBAyCdc20_2
0.711
p.D174N
DO8522
COAD
ICGC
KNDLYRE
LIG_APCC_ABBAyCdc20_2
0.5821
p.D174N
DO42280
UCEC
ICGC
KNDLYRE
LIG_APCC_ABBAyCdc20_2
0.5821
p.D179N
TCGA-AX-A1CE
UCEC
TCGA
KNDLYRE
LIG_APCC_ABBAyCdc20_2
0.3056
p.D179N
TCGA-AZ-6607
COAD
TCGA
KNDLYRE
LIG_APCC_ABBAyCdc20_2
0.3056
p.R181Q
DO39000
THCA
ICGC
KNDLYRE
LIG_APCC_ABBAyCdc20_2
0.25
p.R168Q
TCGA-B5-A11E
UCEC
TCGA
KNDLYRE
LIG_APCC_ABBAyCdc20_2
0.2222
p.R168Q
TCGA-CA-6718
COAD
TCGA
KNDLYRE
LIG_APCC_ABBAyCdc20_2
0.2222
p.L168M
DO37413
SKCM
ICGC
KNDLYRE
LIG_APCC_ABBAyCdc20_2
0.2222
p.R183M
DO43049
UCEC
ICGC
KNDLYRE
LIG_APCC_ABBAyCdc20_2
0.1944
p.R186Q
TCGA-DJ-A1QH
THCA
TCGA
KNDLYRE
LIG_APCC_ABBAyCdc20_2
0.1111
p.R186Q
DO22237
LGG
ICGC
KNDLYRE
LIG_APCC_ABBAyCdc20_2
0.1111
p.R186Q
DO41572
UCEC
ICGC
KNDLYRE
LIG_APCC_ABBAyCdc20_2
0.1111
p.R163W
TCGA-AJ-A3BH
UCEC
TCGA
KNDLYRE
LIG_APCC_ABBAyCdc20_2
0.0833
p.R163W
TCGA-OR-A5J5
ACC
TCGA
KNDLYRE
LIG_APCC_ABBAyCdc20_2
0.0833
p.R163Q
DO7801
COAD
ICGC
KNDLYRE
LIG_APCC_ABBAyCdc20_2
0.0833
p.R163Q
DO41644
UCEC
ICGC
KNDLYRE
LIG_APCC_ABBAyCdc20_2
0.0833
p.R188M
TCGA-D1-A2G0
UCEC
TCGA
KNDLYRE
LIG_APCC_ABBAyCdc20_2
0.0556
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Drug responses associated with SNRNP35 mutations
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Cancer
Mutation (In Degron?)
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Drug
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All proteins holding degron of KNDLYRE
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q16560
U11/U12 small nuclear ribonucleoprotein 35 kDa protein
LIG_APCC_ABBAyCdc20_2
172:178
KNDLYRE
APC,CDC20,FZR1
0.9525
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