DegronMD

Uniprot ID: Q16560

Source protein: U11/U12 small nuclear ribonucleoprotein 35 kDa protein

Source gene: SNRNP35

Class: LIG_APCC_ABBAyCdc20_2

Location: 172:178

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9525

ASA_SCORE: 118.1

COIL: 0.8364

CONS_SCORE: 0.4144

DSS_SCORE: 0.4621

HELIX: 0.1703

FCONS_SCORE: 0.8342

RIG_SCORE: 0.7754

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R163W	TCGA-AJ-A3BH	UCEC	TCGA	KNDLYRE	LIG_APCC_ABBAyCdc20_2	0.0833
p.R163W	TCGA-OR-A5J5	ACC	TCGA	KNDLYRE	LIG_APCC_ABBAyCdc20_2	0.0833
p.D179N	TCGA-AX-A1CE	UCEC	TCGA	KNDLYRE	LIG_APCC_ABBAyCdc20_2	0.3056
p.D179N	TCGA-AZ-6607	COAD	TCGA	KNDLYRE	LIG_APCC_ABBAyCdc20_2	0.3056
p.R168Q	TCGA-B5-A11E	UCEC	TCGA	KNDLYRE	LIG_APCC_ABBAyCdc20_2	0.2222
p.R168Q	TCGA-CA-6718	COAD	TCGA	KNDLYRE	LIG_APCC_ABBAyCdc20_2	0.2222
p.R188M	TCGA-D1-A2G0	UCEC	TCGA	KNDLYRE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R186Q	TCGA-DJ-A1QH	THCA	TCGA	KNDLYRE	LIG_APCC_ABBAyCdc20_2	0.1111
p.R186Q	DO22237	LGG	ICGC	KNDLYRE	LIG_APCC_ABBAyCdc20_2	0.1111
p.R186Q	DO41572	UCEC	ICGC	KNDLYRE	LIG_APCC_ABBAyCdc20_2	0.1111
p.L173M	TCGA-ER-A1A1	SKCM	TCGA	KNDLYRE	LIG_APCC_ABBAyCdc20_2	0.711
p.R163Q	DO7801	COAD	ICGC	KNDLYRE	LIG_APCC_ABBAyCdc20_2	0.0833
p.R163Q	DO41644	UCEC	ICGC	KNDLYRE	LIG_APCC_ABBAyCdc20_2	0.0833
p.D174N	DO8522	COAD	ICGC	KNDLYRE	LIG_APCC_ABBAyCdc20_2	0.5821
p.D174N	DO42280	UCEC	ICGC	KNDLYRE	LIG_APCC_ABBAyCdc20_2	0.5821
p.L168M	DO37413	SKCM	ICGC	KNDLYRE	LIG_APCC_ABBAyCdc20_2	0.2222
p.R181Q	DO39000	THCA	ICGC	KNDLYRE	LIG_APCC_ABBAyCdc20_2	0.25
p.R183M	DO43049	UCEC	ICGC	KNDLYRE	LIG_APCC_ABBAyCdc20_2	0.1944
p.E178G	ACH-001164	Sarcoma	CCLE	KNDLYRE	LIG_APCC_ABBAyCdc20_2	0.7199

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q16560	U11/U12 small nuclear ribonucleoprotein 35 kDa protein	LIG_APCC_ABBAyCdc20_2	172:178	KNDLYRE	APC,CDC20,FZR1	0.9525	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons