DegronMD

Uniprot ID: Q9H2B2

Source protein: Synaptotagmin-4

Source gene: SYT4

Class: LIG_APCC_ABBAyCdc20_2

Location: 89:95

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8521

ASA_SCORE: 96.1143

COIL: 0.787

CONS_SCORE: 0.3516

DSS_SCORE: 0.5785

HELIX: 0.1821

FCONS_SCORE: 0.7248

RIG_SCORE: 0.7342

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A86V	TCGA-55-7995	LUAD	TCGA	KNSLHLD	LIG_APCC_ABBAyCdc20_2	0.25
p.P88Q	TCGA-55-8616	LUAD	TCGA	KNSLHLD	LIG_APCC_ABBAyCdc20_2	0.3056
p.L92M	TCGA-85-6560	LUSC	TCGA	KNSLHLD	LIG_APCC_ABBAyCdc20_2	0.5999
p.K89N	TCGA-AA-A010	COAD	TCGA	KNSLHLD	LIG_APCC_ABBAyCdc20_2	0.6918
p.K89N	TCGA-AP-A1E0	UCEC	TCGA	KNSLHLD	LIG_APCC_ABBAyCdc20_2	0.6918
p.K89N	TCGA-D1-A17Q	UCEC	TCGA	KNSLHLD	LIG_APCC_ABBAyCdc20_2	0.6918
p.K89N	SIDM00193	Colorectal Carcinoma	GDSC	KNSLHLD	LIG_APCC_ABBAyCdc20_2	0.6918
p.K89N	ACH-000991	Colon/Colorectal Cancer	CCLE	KNSLHLD	LIG_APCC_ABBAyCdc20_2	0.6918
p.K89N	SNU-81	large_intestine	COSMIC	KNSLHLD	LIG_APCC_ABBAyCdc20_2	0.6918
p.D100Y	TCGA-AG-A002	READ	TCGA	KNSLHLD	LIG_APCC_ABBAyCdc20_2	0.1944
p.K82N	TCGA-BK-A6W3	UCEC	TCGA	KNSLHLD	LIG_APCC_ABBAyCdc20_2	0.25
p.L101I	TCGA-CR-7367	HNSC	TCGA	KNSLHLD	LIG_APCC_ABBAyCdc20_2	0.1667
p.K98N	TCGA-CV-A45O	HNSC	TCGA	KNSLHLD	LIG_APCC_ABBAyCdc20_2	0.3611
p.L94M	TCGA-DF-A2KU	UCEC	TCGA	KNSLHLD	LIG_APCC_ABBAyCdc20_2	0.5999
p.S91L	TCGA-EE-A29E	SKCM	TCGA	KNSLHLD	LIG_APCC_ABBAyCdc20_2	0.6556
p.P88S	TCGA-EO-A22U	UCEC	TCGA	KNSLHLD	LIG_APCC_ABBAyCdc20_2	0.3056
p.P88S	DO222542	MELA	ICGC	KNSLHLD	LIG_APCC_ABBAyCdc20_2	0.3056
p.P88S	DO51286	SKCM	ICGC	KNSLHLD	LIG_APCC_ABBAyCdc20_2	0.3056
p.T104N	DO844	BLCA	ICGC	KNSLHLD	LIG_APCC_ABBAyCdc20_2	0.0833
p.L100M	DO7783	COAD	ICGC	KNSLHLD	LIG_APCC_ABBAyCdc20_2	0.1944
p.L100M	DO42568	UCEC	ICGC	KNSLHLD	LIG_APCC_ABBAyCdc20_2	0.1944
p.P105S	DO230346	COCA	ICGC	KNSLHLD	LIG_APCC_ABBAyCdc20_2	0.0556
p.K80N	DO49044	HNSC	ICGC	KNSLHLD	LIG_APCC_ABBAyCdc20_2	0.0833
p.L83I	DO15999	HNSC	ICGC	KNSLHLD	LIG_APCC_ABBAyCdc20_2	0.1667
p.G95S	DO219230	KIRC	ICGC	KNSLHLD	LIG_APCC_ABBAyCdc20_2	0.6993
p.N102I	DO22941	LIHC	ICGC	KNSLHLD	LIG_APCC_ABBAyCdc20_2	0.1389
p.N102I	DO22857	LIHC	ICGC	KNSLHLD	LIG_APCC_ABBAyCdc20_2	0.1389
p.P105T	DO25767	LUAD	ICGC	KNSLHLD	LIG_APCC_ABBAyCdc20_2	0.0556
p.P105Q	DO218940	LUAD	ICGC	KNSLHLD	LIG_APCC_ABBAyCdc20_2	0.0556
p.L100Q	DO26230	LUAD	ICGC	KNSLHLD	LIG_APCC_ABBAyCdc20_2	0.1944
p.D99N	DO222908	MELA	ICGC	KNSLHLD	LIG_APCC_ABBAyCdc20_2	0.2222
p.P94S	DO42665	UCEC	ICGC	KNSLHLD	LIG_APCC_ABBAyCdc20_2	0.6752
p.K82E	SIDM01293	Colorectal Carcinoma	GDSC	KNSLHLD	LIG_APCC_ABBAyCdc20_2	0.25
p.E97Q	SIDM00414	Bladder Carcinoma	GDSC	KNSLHLD	LIG_APCC_ABBAyCdc20_2	0.2778
p.E97Q	ACH-000545	Bladder Cancer	CCLE	KNSLHLD	LIG_APCC_ABBAyCdc20_2	0.2778
p.E97Q	VM-CUB-1	urinary_tract	COSMIC	KNSLHLD	LIG_APCC_ABBAyCdc20_2	0.2778
p.L92S	SIDM00936	Bladder Carcinoma	GDSC	KNSLHLD	LIG_APCC_ABBAyCdc20_2	0.7667
p.L92S	ACH-000142	Bladder Cancer	CCLE	KNSLHLD	LIG_APCC_ABBAyCdc20_2	0.7667
p.L92S	CAL-29	urinary_tract	COSMIC	KNSLHLD	LIG_APCC_ABBAyCdc20_2	0.7667
p.E79Q	VM-CUB-1	urinary_tract	COSMIC	KNSLHLD	LIG_APCC_ABBAyCdc20_2	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KNSLHLD

Degron related mutations and impact score

Drug responses associated with SYT4 mutations

All proteins holding degron of KNSLHLD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H2B2	Synaptotagmin-4	LIG_APCC_ABBAyCdc20_2	89:95	KNSLHLD	APC,CDC20,FZR1	0.8521	More...