DegronMD - Q9H2B2(SYT4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A86V	TCGA-55-7995	LUAD	TCGA	KNSLHLD	LIG_APCC_ABBAyCdc20_2	89:95	Mutation rewiring degron network	0.25
p.P88Q	TCGA-55-8616	LUAD	TCGA	KNSLHLD	LIG_APCC_ABBAyCdc20_2	89:95	Mutation rewiring degron network	0.3056
p.I62T	TCGA-55-A48Y	LUAD	TCGA	VDIYPE	LIG_APCC_ABBA_1	60:65	Mutation altering degron motif	0.7078
p.S69I	TCGA-75-5126	LUAD	TCGA	VDIYPE	LIG_APCC_ABBA_1	60:65	Mutation rewiring degron network	0.2222
p.L92M	TCGA-85-6560	LUSC	TCGA	KNSLHLD	LIG_APCC_ABBAyCdc20_2	89:95	Mutation altering degron motif	0.5999
p.K89N	TCGA-AA-A010	COAD	TCGA	KNSLHLD	LIG_APCC_ABBAyCdc20_2	89:95	Mutation altering degron motif	0.6918
p.K89N	TCGA-AP-A1E0	UCEC	TCGA	KNSLHLD	LIG_APCC_ABBAyCdc20_2	89:95	Mutation altering degron motif	0.6918
p.K89N	TCGA-D1-A17Q	UCEC	TCGA	KNSLHLD	LIG_APCC_ABBAyCdc20_2	89:95	Mutation altering degron motif	0.6918
p.K89N	SIDM00193	Colorectal Carcinoma	GDSC	KNSLHLD	LIG_APCC_ABBAyCdc20_2	89:95	Mutation altering degron motif	0.6918
p.K89N	ACH-000991	Colon/Colorectal Cancer	CCLE	KNSLHLD	LIG_APCC_ABBAyCdc20_2	89:95	Mutation altering degron motif	0.6918
p.K89N	SNU-81	large intestine	COSMIC	KNSLHLD	LIG_APCC_ABBAyCdc20_2	89:95	Mutation altering degron motif	0.6918
p.D100Y	TCGA-AG-A002	READ	TCGA	KNSLHLD	LIG_APCC_ABBAyCdc20_2	89:95	Mutation rewiring degron network	0.1944
p.L57F	TCGA-AP-A1DK	UCEC	TCGA	VDIYPE	LIG_APCC_ABBA_1	60:65	Mutation rewiring degron network	0.25
p.L57F	SIDM02035	Colorectal Carcinoma	GDSC	VDIYPE	LIG_APCC_ABBA_1	60:65	Mutation rewiring degron network	0.25
p.K82N	TCGA-BK-A6W3	UCEC	TCGA	KNSLHLD	LIG_APCC_ABBAyCdc20_2	89:95	Mutation substituting flanking lysine	0.25
p.L101I	TCGA-CR-7367	HNSC	TCGA	KNSLHLD	LIG_APCC_ABBAyCdc20_2	89:95	Mutation rewiring degron network	0.1667
p.K98N	TCGA-CV-A45O	HNSC	TCGA	KNSLHLD	LIG_APCC_ABBAyCdc20_2	89:95	Mutation substituting flanking lysine	0.3611
p.K72N	TCGA-D7-A4YU	STAD	TCGA	VDIYPE	LIG_APCC_ABBA_1	60:65	Mutation substituting flanking lysine	0.25
p.L94M	TCGA-DF-A2KU	UCEC	TCGA	KNSLHLD	LIG_APCC_ABBAyCdc20_2	89:95	Mutation altering degron motif	0.5999
p.P50A	TCGA-E6-A1LX	UCEC	TCGA	VDIYPE	LIG_APCC_ABBA_1	60:65	Mutation rewiring degron network	0.0556
p.S91L	TCGA-EE-A29E	SKCM	TCGA	KNSLHLD	LIG_APCC_ABBAyCdc20_2	89:95	Mutation altering degron motif	0.6556
p.P88S	TCGA-EO-A22U	UCEC	TCGA	KNSLHLD	LIG_APCC_ABBAyCdc20_2	89:95	Mutation rewiring degron network	0.3056
p.P88S	DO222542	MELA	ICGC	KNSLHLD	LIG_APCC_ABBAyCdc20_2	89:95	Mutation rewiring degron network	0.3056
p.P88S	DO51286	SKCM	ICGC	KNSLHLD	LIG_APCC_ABBAyCdc20_2	89:95	Mutation rewiring degron network	0.3056
p.D61N	TCGA-OR-A5JK	ACC	TCGA	VDIYPE	LIG_APCC_ABBA_1	60:65	Mutation altering degron motif	0.5821
p.A75T	TCGA-R6-A6L6	ESCA	TCGA	VDIYPE	LIG_APCC_ABBA_1	60:65	Mutation rewiring degron network	0.0556
p.T104N	DO844	BLCA	ICGC	KNSLHLD	LIG_APCC_ABBAyCdc20_2	89:95	Mutation rewiring degron network	0.0833
p.L100M	DO7783	COAD	ICGC	KNSLHLD	LIG_APCC_ABBAyCdc20_2	89:95	Mutation rewiring degron network	0.1944
p.L100M	DO42568	UCEC	ICGC	KNSLHLD	LIG_APCC_ABBAyCdc20_2	89:95	Mutation rewiring degron network	0.1944
p.P105S	DO230346	COCA	ICGC	KNSLHLD	LIG_APCC_ABBAyCdc20_2	89:95	Mutation rewiring degron network	0.0556
p.K54T	DO233689	GACA	ICGC	VDIYPE	LIG_APCC_ABBA_1	60:65	Mutation rewiring degron network	0.1667
p.K80N	DO49044	HNSC	ICGC	KNSLHLD	LIG_APCC_ABBAyCdc20_2	89:95	Mutation rewiring degron network	0.0833
p.L83I	DO15999	HNSC	ICGC	KNSLHLD	LIG_APCC_ABBAyCdc20_2	89:95	Mutation rewiring degron network	0.1667
p.G95S	DO219230	KIRC	ICGC	KNSLHLD	LIG_APCC_ABBAyCdc20_2	89:95	Mutation altering degron motif	0.6993
p.P67T	DO229041	LICA	ICGC	VDIYPE	LIG_APCC_ABBA_1	60:65	Mutation rewiring degron network	0.2778
p.P67T	DO229006	LICA	ICGC	VDIYPE	LIG_APCC_ABBA_1	60:65	Mutation rewiring degron network	0.2778
p.N102I	DO22941	LIHC	ICGC	KNSLHLD	LIG_APCC_ABBAyCdc20_2	89:95	Mutation rewiring degron network	0.1389
p.N102I	DO22857	LIHC	ICGC	KNSLHLD	LIG_APCC_ABBAyCdc20_2	89:95	Mutation rewiring degron network	0.1389
p.P105T	DO25767	LUAD	ICGC	KNSLHLD	LIG_APCC_ABBAyCdc20_2	89:95	Mutation rewiring degron network	0.0556
p.P105Q	DO218940	LUAD	ICGC	KNSLHLD	LIG_APCC_ABBAyCdc20_2	89:95	Mutation rewiring degron network	0.0556
p.S51I	DO23711	LUAD	ICGC	VDIYPE	LIG_APCC_ABBA_1	60:65	Mutation rewiring degron network	0.0833
p.A68V	DO45323	LUAD	ICGC	VDIYPE	LIG_APCC_ABBA_1	60:65	Mutation rewiring degron network	0.25
p.D59Y	DO23961	LUAD	ICGC	VDIYPE	LIG_APCC_ABBA_1	60:65	Mutation rewiring degron network	0.3056
p.P70Q	DO23566	LUAD	ICGC	VDIYPE	LIG_APCC_ABBA_1	60:65	Mutation blocking ubiquitination signal	0.6389
p.L100Q	DO26230	LUAD	ICGC	KNSLHLD	LIG_APCC_ABBAyCdc20_2	89:95	Mutation rewiring degron network	0.1944
p.E62Q	DO230535	LUSC	ICGC	VDIYPE	LIG_APCC_ABBA_1	60:65	Mutation altering degron motif	0.6744
p.L74M	DO26752	LUSC	ICGC	VDIYPE	LIG_APCC_ABBA_1	60:65	Mutation rewiring degron network	0.0833
p.D99N	DO222908	MELA	ICGC	KNSLHLD	LIG_APCC_ABBAyCdc20_2	89:95	Mutation rewiring degron network	0.2222
p.K60T	DO36881	READ	ICGC	VDIYPE	LIG_APCC_ABBA_1	60:65	Mutation altering degron motif	0.7306
p.S73L	DO37831	SKCM	ICGC	VDIYPE	LIG_APCC_ABBA_1	60:65	Mutation rewiring degron network	0.1111
p.K54N	DO47761	STAD	ICGC	VDIYPE	LIG_APCC_ABBA_1	60:65	Mutation rewiring degron network	0.1667
p.K64N	DO50076	UCEC	ICGC	VDIYPE	LIG_APCC_ABBA_1	60:65	Mutation altering degron motif	0.6918
p.K71N	DO43154	UCEC	ICGC	VDIYPE	LIG_APCC_ABBA_1	60:65	Mutation substituting flanking lysine	0.2778
p.K71N	DO41903	UCEC	ICGC	VDIYPE	LIG_APCC_ABBA_1	60:65	Mutation substituting flanking lysine	0.2778
p.K71N	SIDM01588	Endometrial Carcinoma	GDSC	VDIYPE	LIG_APCC_ABBA_1	60:65	Mutation substituting flanking lysine	0.2778
p.K71N	ACH-000993	Endometrial/Uterine Cancer	CCLE	VDIYPE	LIG_APCC_ABBA_1	60:65	Mutation substituting flanking lysine	0.2778
p.K71N	SNU-81	large intestine	COSMIC	VDIYPE	LIG_APCC_ABBA_1	60:65	Mutation substituting flanking lysine	0.2778
p.P70S	DO43755	UCEC	ICGC	VDIYPE	LIG_APCC_ABBA_1	60:65	Mutation blocking ubiquitination signal	0.6389
p.P94S	DO42665	UCEC	ICGC	KNSLHLD	LIG_APCC_ABBAyCdc20_2	89:95	Mutation altering degron motif	0.6752
p.K82E	SIDM01293	Colorectal Carcinoma	GDSC	KNSLHLD	LIG_APCC_ABBAyCdc20_2	89:95	Mutation substituting flanking lysine	0.25
p.P50T	SIDM00924	Other Solid Cancers	GDSC	VDIYPE	LIG_APCC_ABBA_1	60:65	Mutation rewiring degron network	0.0556
p.P50T	ACH-000867	Lung Cancer	CCLE	VDIYPE	LIG_APCC_ABBA_1	60:65	Mutation rewiring degron network	0.0556
p.P50T	ChaGo-K-1	lung	COSMIC	VDIYPE	LIG_APCC_ABBA_1	60:65	Mutation rewiring degron network	0.0556
p.P50S	SIDM00327	Hodgkin's Lymphoma	GDSC	VDIYPE	LIG_APCC_ABBA_1	60:65	Mutation rewiring degron network	0.0556
p.P50S	ACH-000754	Lymphoma	CCLE	VDIYPE	LIG_APCC_ABBA_1	60:65	Mutation rewiring degron network	0.0556
p.P50S	L-428	haematopoietic and lymphoid tissue	COSMIC	VDIYPE	LIG_APCC_ABBA_1	60:65	Mutation rewiring degron network	0.0556
p.V56G	SIDM00983	Bladder Carcinoma	GDSC	VDIYPE	LIG_APCC_ABBA_1	60:65	Mutation rewiring degron network	0.2222
p.V56G	ACH-000896	Bladder Cancer	CCLE	VDIYPE	LIG_APCC_ABBA_1	60:65	Mutation rewiring degron network	0.2222
p.V56G	647-V	urinary tract	COSMIC	VDIYPE	LIG_APCC_ABBA_1	60:65	Mutation rewiring degron network	0.2222
p.E97Q	SIDM00414	Bladder Carcinoma	GDSC	KNSLHLD	LIG_APCC_ABBAyCdc20_2	89:95	Mutation rewiring degron network	0.2778
p.E97Q	ACH-000545	Bladder Cancer	CCLE	KNSLHLD	LIG_APCC_ABBAyCdc20_2	89:95	Mutation rewiring degron network	0.2778
p.E97Q	VM-CUB-1	urinary tract	COSMIC	KNSLHLD	LIG_APCC_ABBAyCdc20_2	89:95	Mutation rewiring degron network	0.2778
p.L92S	SIDM00936	Bladder Carcinoma	GDSC	KNSLHLD	LIG_APCC_ABBAyCdc20_2	89:95	Mutation altering degron motif	0.7667
p.L92S	ACH-000142	Bladder Cancer	CCLE	KNSLHLD	LIG_APCC_ABBAyCdc20_2	89:95	Mutation altering degron motif	0.7667
p.L92S	CAL-29	urinary tract	COSMIC	KNSLHLD	LIG_APCC_ABBAyCdc20_2	89:95	Mutation altering degron motif	0.7667
p.H55D	ACH-000279	Bone Cancer	CCLE	VDIYPE	LIG_APCC_ABBA_1	60:65	Mutation rewiring degron network	0.1944
p.L74S	CAL-29	urinary tract	COSMIC	VDIYPE	LIG_APCC_ABBA_1	60:65	Mutation rewiring degron network	0.0833
p.E79Q	VM-CUB-1	urinary tract	COSMIC	KNSLHLD	LIG_APCC_ABBAyCdc20_2	89:95	Mutation rewiring degron network	0.0556

Kaplan plot for SYT4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SYT4

UniProt ID: Q9H2B2

Entrez ID: 6860

Protein name: Synaptotagmin-4 (Synaptotagmin IV) (SytIV)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SYT4 in