DegronMD

Uniprot ID: Q9H2B2

Source protein: Synaptotagmin-4

Source gene: SYT4

Class: LIG_APCC_ABBA_1

Location: 60:65

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7972

ASA_SCORE: 85.9667

COIL: 0.6977

CONS_SCORE: 0.5595

DSS_SCORE: 0.2416

HELIX: 0.1407

FCONS_SCORE: 1.0899

RIG_SCORE: 0.8081

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I62T	TCGA-55-A48Y	LUAD	TCGA	VDIYPE	LIG_APCC_ABBA_1	0.7078
p.S69I	TCGA-75-5126	LUAD	TCGA	VDIYPE	LIG_APCC_ABBA_1	0.2222
p.L57F	TCGA-AP-A1DK	UCEC	TCGA	VDIYPE	LIG_APCC_ABBA_1	0.25
p.L57F	SIDM02035	Colorectal Carcinoma	GDSC	VDIYPE	LIG_APCC_ABBA_1	0.25
p.K72N	TCGA-D7-A4YU	STAD	TCGA	VDIYPE	LIG_APCC_ABBA_1	0.25
p.P50A	TCGA-E6-A1LX	UCEC	TCGA	VDIYPE	LIG_APCC_ABBA_1	0.0556
p.D61N	TCGA-OR-A5JK	ACC	TCGA	VDIYPE	LIG_APCC_ABBA_1	0.5821
p.A75T	TCGA-R6-A6L6	ESCA	TCGA	VDIYPE	LIG_APCC_ABBA_1	0.0556
p.K54T	DO233689	GACA	ICGC	VDIYPE	LIG_APCC_ABBA_1	0.1667
p.P67T	DO229041	LICA	ICGC	VDIYPE	LIG_APCC_ABBA_1	0.2778
p.P67T	DO229006	LICA	ICGC	VDIYPE	LIG_APCC_ABBA_1	0.2778
p.S51I	DO23711	LUAD	ICGC	VDIYPE	LIG_APCC_ABBA_1	0.0833
p.A68V	DO45323	LUAD	ICGC	VDIYPE	LIG_APCC_ABBA_1	0.25
p.D59Y	DO23961	LUAD	ICGC	VDIYPE	LIG_APCC_ABBA_1	0.3056
p.P70Q	DO23566	LUAD	ICGC	VDIYPE	LIG_APCC_ABBA_1	0.6389
p.E62Q	DO230535	LUSC	ICGC	VDIYPE	LIG_APCC_ABBA_1	0.6744
p.L74M	DO26752	LUSC	ICGC	VDIYPE	LIG_APCC_ABBA_1	0.0833
p.K60T	DO36881	READ	ICGC	VDIYPE	LIG_APCC_ABBA_1	0.7306
p.S73L	DO37831	SKCM	ICGC	VDIYPE	LIG_APCC_ABBA_1	0.1111
p.K54N	DO47761	STAD	ICGC	VDIYPE	LIG_APCC_ABBA_1	0.1667
p.K64N	DO50076	UCEC	ICGC	VDIYPE	LIG_APCC_ABBA_1	0.6918
p.K71N	DO43154	UCEC	ICGC	VDIYPE	LIG_APCC_ABBA_1	0.2778
p.K71N	DO41903	UCEC	ICGC	VDIYPE	LIG_APCC_ABBA_1	0.2778
p.K71N	SIDM01588	Endometrial Carcinoma	GDSC	VDIYPE	LIG_APCC_ABBA_1	0.2778
p.K71N	ACH-000993	Endometrial/Uterine Cancer	CCLE	VDIYPE	LIG_APCC_ABBA_1	0.2778
p.K71N	SNU-81	large_intestine	COSMIC	VDIYPE	LIG_APCC_ABBA_1	0.2778
p.P70S	DO43755	UCEC	ICGC	VDIYPE	LIG_APCC_ABBA_1	0.6389
p.P50T	SIDM00924	Other Solid Cancers	GDSC	VDIYPE	LIG_APCC_ABBA_1	0.0556
p.P50T	ACH-000867	Lung Cancer	CCLE	VDIYPE	LIG_APCC_ABBA_1	0.0556
p.P50T	ChaGo-K-1	lung	COSMIC	VDIYPE	LIG_APCC_ABBA_1	0.0556
p.P50S	SIDM00327	Hodgkin's Lymphoma	GDSC	VDIYPE	LIG_APCC_ABBA_1	0.0556
p.P50S	ACH-000754	Lymphoma	CCLE	VDIYPE	LIG_APCC_ABBA_1	0.0556
p.P50S	L-428	haematopoietic_and_lymphoid_tissue	COSMIC	VDIYPE	LIG_APCC_ABBA_1	0.0556
p.V56G	SIDM00983	Bladder Carcinoma	GDSC	VDIYPE	LIG_APCC_ABBA_1	0.2222
p.V56G	ACH-000896	Bladder Cancer	CCLE	VDIYPE	LIG_APCC_ABBA_1	0.2222
p.V56G	647-V	urinary_tract	COSMIC	VDIYPE	LIG_APCC_ABBA_1	0.2222
p.H55D	ACH-000279	Bone Cancer	CCLE	VDIYPE	LIG_APCC_ABBA_1	0.1944
p.L74S	CAL-29	urinary_tract	COSMIC	VDIYPE	LIG_APCC_ABBA_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VDIYPE

Degron related mutations and impact score

Drug responses associated with SYT4 mutations

All proteins holding degron of VDIYPE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H2B2	Synaptotagmin-4	LIG_APCC_ABBA_1	60:65	VDIYPE	APC,CDC20,FZR1	0.7972	More...