DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
KPGIYED
Uniprot ID:
Q9C0D2
Source protein:
Centrosomal protein of 295 kDa
Source gene:
CEP295
Class:
LIG_APCC_ABBAyCdc20_2
Location:
1867:1873
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.827
ASA_SCORE:
95.4286
COIL:
0.8777
CONS_SCORE:
0.3889
DSS_SCORE:
0.3734
HELIX:
0.0389
FCONS_SCORE:
0.8226
RIG_SCORE:
0.736
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with CEP295 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of KPGIYED
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9C0D2
Centrosomal protein of 295 kDa
LIG_APCC_ABBAyCdc20_2
1867:1873
KPGIYED
APC,CDC20,FZR1
0.827
More...