DegronMD

Uniprot ID: Q5VWQ0

Source protein: Lysine-specific demethylase 9

Source gene: RSBN1

Class: DEG_SIAH_1

Location: 75:83

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.7751

ASA_SCORE: 87.8333

COIL: 0.8083

CONS_SCORE: 0.452

DSS_SCORE: 0.8065

HELIX: 0.0377

FCONS_SCORE: 0.9708

RIG_SCORE: 0.5961

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q88K	TCGA-55-7910	LUAD	TCGA	KPHAGVSPR	DEG_SIAH_1	0.1944
p.Q88K	DO23669	LUAD	ICGC	KPHAGVSPR	DEG_SIAH_1	0.1944
p.V85A	TCGA-86-A4JF	LUAD	TCGA	KPHAGVSPR	DEG_SIAH_1	0.2778
p.V85A	DO45317	LUAD	ICGC	KPHAGVSPR	DEG_SIAH_1	0.2778
p.V85L	TCGA-DD-AACI	LIHC	TCGA	KPHAGVSPR	DEG_SIAH_1	0.2778
p.V85L	DO52205	LIHC	ICGC	KPHAGVSPR	DEG_SIAH_1	0.2778
p.P68S	DO233764	GACA	ICGC	KPHAGVSPR	DEG_SIAH_1	0.1389
p.S91F	SIDM01265	Plasma Cell Myeloma	GDSC	KPHAGVSPR	DEG_SIAH_1	0.5556
p.S91F	ACH-000763	Myeloma	CCLE	KPHAGVSPR	DEG_SIAH_1	0.5556
p.S91F	MM1S	haematopoietic_and_lymphoid_tissue	COSMIC	KPHAGVSPR	DEG_SIAH_1	0.5556
p.R89L	SIDM00541	Colorectal Carcinoma	GDSC	KPHAGVSPR	DEG_SIAH_1	0.1667
p.R89L	ACH-000926	Colon/Colorectal Cancer	CCLE	KPHAGVSPR	DEG_SIAH_1	0.1667
p.R89L	HT55	large_intestine	COSMIC	KPHAGVSPR	DEG_SIAH_1	0.1667
p.H80R	EN	endometrium	COSMIC	KPHAGVSPR	DEG_SIAH_1	0.8244
p.S89F	NCI-H187	lung	COSMIC	KPHAGVSPR	DEG_SIAH_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VWQ0	Lysine-specific demethylase 9	DEG_SIAH_1	75:83	KPHAGVSPR	SIAH1,SIAH2,SIAH3	0.7751	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons