DegronMD - Q5VWQ0(RSBN1)

FUNCTION: Histone demethylase that specifically demethylates dimethylated 'Lys-20' of histone H4 (H4K20me2), thereby modulating chromosome architecture. {ECO:0000250|UniProtKB:Q80T69}.

GO - Biological processes (BP): chromatin organization [GO:0006325]

GO - Molecular function (MF): dioxygenase activity [GO:0051213]; metal ion binding [GO:0046872]

GO - Cellular component (CC): nucleus [GO:0005634]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H80R	EN	endometrium	COSMIC	KPHAGVSPR	DEG_SIAH_1	75:83	Mutation altering degron motif	0.8244
p.P336L	TCGA-EE-A2GH	SKCM	TCGA	VQTPFMT	DEG_SCF_FBW7_1	333:339	Mutation altering degron motif	0.7582
p.P336L	DO37643	SKCM	ICGC	VQTPFMT	DEG_SCF_FBW7_1	333:339	Mutation altering degron motif	0.7582
p.S91F	SIDM01265	Plasma Cell Myeloma	GDSC	KPHAGVSPR	DEG_SIAH_1	75:83	Mutation blocking phosphorylation signal	0.5556
p.S91F	ACH-000763	Myeloma	CCLE	KPHAGVSPR	DEG_SIAH_1	75:83	Mutation blocking phosphorylation signal	0.5556
p.S91F	MM1S	haematopoietic and lymphoid tissue	COSMIC	KPHAGVSPR	DEG_SIAH_1	75:83	Mutation blocking phosphorylation signal	0.5556
p.V85A	TCGA-86-A4JF	LUAD	TCGA	KPHAGVSPR	DEG_SIAH_1	75:83	Mutation rewiring degron network	0.2778
p.V85A	DO45317	LUAD	ICGC	KPHAGVSPR	DEG_SIAH_1	75:83	Mutation rewiring degron network	0.2778
p.V85L	TCGA-DD-AACI	LIHC	TCGA	KPHAGVSPR	DEG_SIAH_1	75:83	Mutation rewiring degron network	0.2778
p.V85L	DO52205	LIHC	ICGC	KPHAGVSPR	DEG_SIAH_1	75:83	Mutation rewiring degron network	0.2778
p.Q88K	TCGA-55-7910	LUAD	TCGA	KPHAGVSPR	DEG_SIAH_1	75:83	Mutation rewiring degron network	0.1944
p.Q88K	DO23669	LUAD	ICGC	KPHAGVSPR	DEG_SIAH_1	75:83	Mutation rewiring degron network	0.1944
p.R89L	SIDM00541	Colorectal Carcinoma	GDSC	KPHAGVSPR	DEG_SIAH_1	75:83	Mutation rewiring degron network	0.1667
p.R89L	ACH-000926	Colon/Colorectal Cancer	CCLE	KPHAGVSPR	DEG_SIAH_1	75:83	Mutation rewiring degron network	0.1667
p.R89L	HT55	large intestine	COSMIC	KPHAGVSPR	DEG_SIAH_1	75:83	Mutation rewiring degron network	0.1667
p.S89F	NCI-H187	lung	COSMIC	KPHAGVSPR	DEG_SIAH_1	75:83	Mutation rewiring degron network	0.1667
p.R346C	TCGA-A5-A2K5	UCEC	TCGA	VQTPFMT	DEG_SCF_FBW7_1	333:339	Mutation rewiring degron network	0.1389
p.R346C	TCGA-AX-A05Z	UCEC	TCGA	VQTPFMT	DEG_SCF_FBW7_1	333:339	Mutation rewiring degron network	0.1389
p.R346C	DO40884	UCEC	ICGC	VQTPFMT	DEG_SCF_FBW7_1	333:339	Mutation rewiring degron network	0.1389
p.R346C	DO41379	UCEC	ICGC	VQTPFMT	DEG_SCF_FBW7_1	333:339	Mutation rewiring degron network	0.1389

Showing 1 to 20 of 28 entries

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No resistance data available for this Degron.

Kaplan plot for RSBN1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RSBN1

UniProt ID: Q5VWQ0

Entrez ID: 54665

Protein name: Lysine-specific demethylase 9 (KDM9) (EC 1.14.11.-) (Round spermatid basic protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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No resistance data available for this Degron.

Kaplan plot for RSBN1 in