DegronMD

Uniprot ID: Q5VWQ0

Source protein: Lysine-specific demethylase 9

Source gene: RSBN1

Class: DEG_SCF_FBW7_1

Location: 333:339

E3 ligase: FBXW7

DEGRON score: 0.6305

ASA_SCORE: 76.1429

COIL: 0.8149

CONS_SCORE: 0.4557

DSS_SCORE: 0.4829

HELIX: 0.1191

FCONS_SCORE: 0.9122

RIG_SCORE: 0.7356

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R346C	TCGA-A5-A2K5	UCEC	TCGA	VQTPFMT	DEG_SCF_FBW7_1	0.1389
p.R346C	TCGA-AX-A05Z	UCEC	TCGA	VQTPFMT	DEG_SCF_FBW7_1	0.1389
p.R346C	DO40884	UCEC	ICGC	VQTPFMT	DEG_SCF_FBW7_1	0.1389
p.R346C	DO41379	UCEC	ICGC	VQTPFMT	DEG_SCF_FBW7_1	0.1389
p.R347K	TCGA-AJ-A3EK	UCEC	TCGA	VQTPFMT	DEG_SCF_FBW7_1	0.1111
p.R347K	DO41584	UCEC	ICGC	VQTPFMT	DEG_SCF_FBW7_1	0.1111
p.R347I	TCGA-E6-A1LX	UCEC	TCGA	VQTPFMT	DEG_SCF_FBW7_1	0.1111
p.R347I	DO41020	UCEC	ICGC	VQTPFMT	DEG_SCF_FBW7_1	0.1111
p.R346H	TCGA-E6-A1LX	UCEC	TCGA	VQTPFMT	DEG_SCF_FBW7_1	0.1389
p.R346H	DO41020	UCEC	ICGC	VQTPFMT	DEG_SCF_FBW7_1	0.1389
p.P336L	TCGA-EE-A2GH	SKCM	TCGA	VQTPFMT	DEG_SCF_FBW7_1	0.7582
p.P336L	DO37643	SKCM	ICGC	VQTPFMT	DEG_SCF_FBW7_1	0.7582
p.L325F	Hs939-T	skin	COSMIC	VQTPFMT	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VWQ0	Lysine-specific demethylase 9	DEG_SCF_FBW7_1	333:339	VQTPFMT	FBXW7	0.6305	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons