DegronMD

Uniprot ID: P12644

Source protein: Bone morphogenetic protein 4

Source gene: BMP4

Class: DEG_SIAH_1

Location: 185:193

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9447

ASA_SCORE: 76.7

COIL: 0.8363

CONS_SCORE: 0.382

DSS_SCORE: 0.1676

HELIX: 0.0361

FCONS_SCORE: 0.7111

RIG_SCORE: 0.7724

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I196M	TCGA-56-8622	LUSC	TCGA	KPPAEVVPG	DEG_SIAH_1	0.25
p.I196M	DO45449	LUSC	ICGC	KPPAEVVPG	DEG_SIAH_1	0.25
p.R203T	TCGA-56-A49D	LUSC	TCGA	KPPAEVVPG	DEG_SIAH_1	0.0556
p.R203T	DO45475	LUSC	ICGC	KPPAEVVPG	DEG_SIAH_1	0.0556
p.A188S	TCGA-79-5596	LUSC	TCGA	KPPAEVVPG	DEG_SIAH_1	0.7588
p.A188S	DO27357	LUSC	ICGC	KPPAEVVPG	DEG_SIAH_1	0.7588
p.P192L	TCGA-AX-A2HD	UCEC	TCGA	KPPAEVVPG	DEG_SIAH_1	0.7582
p.P192L	DO42608	UCEC	ICGC	KPPAEVVPG	DEG_SIAH_1	0.7582
p.R198Q	TCGA-B0-5098	KIRC	TCGA	KPPAEVVPG	DEG_SIAH_1	0.1944
p.R198Q	DO18938	KIRC	ICGC	KPPAEVVPG	DEG_SIAH_1	0.1944
p.K185E	TCGA-B5-A3FC	UCEC	TCGA	KPPAEVVPG	DEG_SIAH_1	0.591
p.K185E	DO41871	UCEC	ICGC	KPPAEVVPG	DEG_SIAH_1	0.591
p.I180V	TCGA-EO-A22R	UCEC	TCGA	KPPAEVVPG	DEG_SIAH_1	0.1944
p.I180V	DO42713	UCEC	ICGC	KPPAEVVPG	DEG_SIAH_1	0.1944
p.V190A	TCGA-IB-7651	PAAD	TCGA	KPPAEVVPG	DEG_SIAH_1	0.6936
p.V190A	DO46657	PAAD	ICGC	KPPAEVVPG	DEG_SIAH_1	0.6936
p.L199P	SIDM01004	Chronic Myelogenous Leukemia	GDSC	KPPAEVVPG	DEG_SIAH_1	0.1667
p.L199P	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	KPPAEVVPG	DEG_SIAH_1	0.1667
p.L199P	ACH-000917	Esophageal Cancer	CCLE	KPPAEVVPG	DEG_SIAH_1	0.1667
p.L199P	ACH-000983	Leukemia	CCLE	KPPAEVVPG	DEG_SIAH_1	0.1667
p.L199P	TE-4	oesophagus	COSMIC	KPPAEVVPG	DEG_SIAH_1	0.1667
p.L199P	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	KPPAEVVPG	DEG_SIAH_1	0.1667
p.V190M	SIDM00845	Burkitt's Lymphoma	GDSC	KPPAEVVPG	DEG_SIAH_1	0.7208
p.V190M	ACH-000992	Head and Neck Cancer	CCLE	KPPAEVVPG	DEG_SIAH_1	0.7208
p.E182D	SIDM00965	Small Cell Lung Carcinoma	GDSC	KPPAEVVPG	DEG_SIAH_1	0.25
p.E182D	ACH-000800	Lung Cancer	CCLE	KPPAEVVPG	DEG_SIAH_1	0.25
p.E182D	NCI-H446	lung	COSMIC	KPPAEVVPG	DEG_SIAH_1	0.25
p.T202M	SIDM00936	Bladder Carcinoma	GDSC	KPPAEVVPG	DEG_SIAH_1	0.0833
p.T202M	ACH-000142	Bladder Cancer	CCLE	KPPAEVVPG	DEG_SIAH_1	0.0833
p.T202M	CAL-29	urinary_tract	COSMIC	KPPAEVVPG	DEG_SIAH_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KPPAEVVPG

Degron related mutations and impact score

Drug responses associated with BMP4 mutations

All proteins holding degron of KPPAEVVPG

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P12644	Bone morphogenetic protein 4	DEG_SIAH_1	185:193	KPPAEVVPG	SIAH1,SIAH2,SIAH3	0.9447	More...