DegronMD

Uniprot ID: O95067

Source protein: G2/mitotic-specific cyclin-B2

Source gene: CCNB2

Class: DEG_SIAH_1

Location: 73:81

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9983

ASA_SCORE: 97.0889

COIL: 0.8628

CONS_SCORE: 0.2591

DSS_SCORE: 0.6129

HELIX: 0.0933

FCONS_SCORE: 1.1166

RIG_SCORE: 0.7161

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P80S	TCGA-19-5956	GBM	TCGA	KPTASVKPV	DEG_SIAH_1	0.6752
p.P80S	DO13863	GBM	ICGC	KPTASVKPV	DEG_SIAH_1	0.6752
p.V68I	TCGA-AX-A06F	UCEC	TCGA	KPTASVKPV	DEG_SIAH_1	0.1944
p.V68I	DO41752	UCEC	ICGC	KPTASVKPV	DEG_SIAH_1	0.1944
p.V68I	SIDM00619	Thyroid Gland Carcinoma	GDSC	KPTASVKPV	DEG_SIAH_1	0.1944
p.V68I	ACH-002397	Thyroid Cancer	CCLE	KPTASVKPV	DEG_SIAH_1	0.1944
p.V68I	KMH-2	thyroid	COSMIC	KPTASVKPV	DEG_SIAH_1	0.1944
p.A87V	TCGA-BH-A0HF	BRCA	TCGA	KPTASVKPV	DEG_SIAH_1	0.1667
p.A87V	DO1749	BRCA	ICGC	KPTASVKPV	DEG_SIAH_1	0.1667
p.T66K	TCGA-DI-A1BU	UCEC	TCGA	KPTASVKPV	DEG_SIAH_1	0.1389
p.T66K	DO42023	UCEC	ICGC	KPTASVKPV	DEG_SIAH_1	0.1389
p.E84D	TCGA-ND-A4WC	UCS	TCGA	KPTASVKPV	DEG_SIAH_1	0.25
p.R83C	DO10092	COAD	ICGC	KPTASVKPV	DEG_SIAH_1	0.2778
p.R83C	DO222501	COCA	ICGC	KPTASVKPV	DEG_SIAH_1	0.2778
p.R85C	DO7776	COAD	ICGC	KPTASVKPV	DEG_SIAH_1	0.6667
p.R85C	DO223658	PRAD	ICGC	KPTASVKPV	DEG_SIAH_1	0.6667
p.R85C	NCI-H630	large_intestine	COSMIC	KPTASVKPV	DEG_SIAH_1	0.6667
p.D90H	DO230961	LUSC	ICGC	KPTASVKPV	DEG_SIAH_1	0.0833
p.V68D	SIDM00619	Thyroid Gland Carcinoma	GDSC	KPTASVKPV	DEG_SIAH_1	0.1944
p.V68D	ACH-002397	Thyroid Cancer	CCLE	KPTASVKPV	DEG_SIAH_1	0.1944
p.V68D	KMH-2	thyroid	COSMIC	KPTASVKPV	DEG_SIAH_1	0.1944
p.T75I	SIDM00886	B-Cell Non-Hodgkin's Lymphoma	GDSC	KPTASVKPV	DEG_SIAH_1	0.5966
p.T75I	ACH-000334	Lymphoma	CCLE	KPTASVKPV	DEG_SIAH_1	0.5966
p.T75I	DB	haematopoietic_and_lymphoid_tissue	COSMIC	KPTASVKPV	DEG_SIAH_1	0.5966
p.G90V	SIDM01336	Glioblastoma	GDSC	KPTASVKPV	DEG_SIAH_1	0.0833
p.R83H	OCUB-M	breast	COSMIC	KPTASVKPV	DEG_SIAH_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95067	G2/mitotic-specific cyclin-B2	DEG_SIAH_1	73:81	KPTASVKPV	SIAH1,SIAH2,SIAH3	0.9983	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons