DegronMD - O95067(CCNB2)

FUNCTION: Essential for the control of the cell cycle at the G2/M (mitosis) transition.

GO - Biological processes (BP): cell division [GO:0051301]; G2/MI transition of meiotic cell cycle [GO:0008315]; in utero embryonic development [GO:0001701]; mitotic cell cycle phase transition [GO:0044772]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of growth [GO:0040008]; spi... View more >>

GO - Molecular function (MF): cadherin binding [GO:0045296]; cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]

GO - Cellular component (CC): centrosome [GO:0005813]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R31M	TCGA-77-7142	LUSC	TCGA	RRTVLEEIG	DEG_APCC_DBOX_1	31:39	Mutation altering degron motif	0.7521
p.R31M	DO26462	LUSC	ICGC	RRTVLEEIG	DEG_APCC_DBOX_1	31:39	Mutation altering degron motif	0.7521
p.R32Q	TCGA-A5-A0GP	UCEC	TCGA	RRTVLEEIG	DEG_APCC_DBOX_1	31:39	Mutation altering degron motif	0.7329
p.R32Q	TCGA-AX-A0J0	UCEC	TCGA	RRTVLEEIG	DEG_APCC_DBOX_1	31:39	Mutation altering degron motif	0.7329
p.R32Q	TCGA-IB-7651	PAAD	TCGA	RRTVLEEIG	DEG_APCC_DBOX_1	31:39	Mutation altering degron motif	0.7329
p.R32Q	DO46657	PAAD	ICGC	RRTVLEEIG	DEG_APCC_DBOX_1	31:39	Mutation altering degron motif	0.7329
p.R32Q	DO41109	UCEC	ICGC	RRTVLEEIG	DEG_APCC_DBOX_1	31:39	Mutation altering degron motif	0.7329
p.R32Q	DO41133	UCEC	ICGC	RRTVLEEIG	DEG_APCC_DBOX_1	31:39	Mutation altering degron motif	0.7329
p.P80S	TCGA-19-5956	GBM	TCGA	KPTASVKPV	DEG_SIAH_1	73:81	Mutation altering degron motif	0.6752
p.P80S	DO13863	GBM	ICGC	KPTASVKPV	DEG_SIAH_1	73:81	Mutation altering degron motif	0.6752
p.R85C	DO7776	COAD	ICGC	KPTASVKPV	DEG_SIAH_1	73:81	Mutation blocking ubiquitination signal	0.6667
p.R85C	DO223658	PRAD	ICGC	KPTASVKPV	DEG_SIAH_1	73:81	Mutation blocking ubiquitination signal	0.6667
p.R85C	NCI-H630	large intestine	COSMIC	KPTASVKPV	DEG_SIAH_1	73:81	Mutation blocking ubiquitination signal	0.6667
p.T33A	SIDM00278	Esophageal Squamous Cell Carcinoma	GDSC	RRTVLEEIG	DEG_APCC_DBOX_1	31:39	Mutation altering degron motif	0.6028
p.T33A	EC-GI-10	oesophagus	COSMIC	RRTVLEEIG	DEG_APCC_DBOX_1	31:39	Mutation altering degron motif	0.6028
p.T75I	SIDM00886	B-Cell Non-Hodgkin's Lymphoma	GDSC	KPTASVKPV	DEG_SIAH_1	73:81	Mutation altering degron motif	0.5966
p.T75I	ACH-000334	Lymphoma	CCLE	KPTASVKPV	DEG_SIAH_1	73:81	Mutation altering degron motif	0.5966
p.T75I	DB	haematopoietic and lymphoid tissue	COSMIC	KPTASVKPV	DEG_SIAH_1	73:81	Mutation altering degron motif	0.5966
p.E37K	NCI-H2135	lung	COSMIC	RRTVLEEIG	DEG_APCC_DBOX_1	31:39	Mutation altering degron motif	0.591
p.R83C	DO10092	COAD	ICGC	KPTASVKPV	DEG_SIAH_1	73:81	Mutation rewiring degron network	0.2778

Showing 1 to 20 of 39 entries

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Kaplan plot for CCNB2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CCNB2

UniProt ID: O95067

Entrez ID: 9133

Protein name: G2/mitotic-specific cyclin-B2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CCNB2 in