DegronMD - O95067(CCNB2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P80S	TCGA-19-5956	GBM	TCGA	KPTASVKPV	DEG_SIAH_1	73:81	Mutation altering degron motif	0.6752
p.P80S	DO13863	GBM	ICGC	KPTASVKPV	DEG_SIAH_1	73:81	Mutation altering degron motif	0.6752
p.R31M	TCGA-77-7142	LUSC	TCGA	RRTVLEEIG	DEG_APCC_DBOX_1	31:39	Mutation altering degron motif	0.7521
p.R31M	DO26462	LUSC	ICGC	RRTVLEEIG	DEG_APCC_DBOX_1	31:39	Mutation altering degron motif	0.7521
p.R32Q	TCGA-A5-A0GP	UCEC	TCGA	RRTVLEEIG	DEG_APCC_DBOX_1	31:39	Mutation altering degron motif	0.7329
p.R32Q	TCGA-AX-A0J0	UCEC	TCGA	RRTVLEEIG	DEG_APCC_DBOX_1	31:39	Mutation altering degron motif	0.7329
p.R32Q	TCGA-IB-7651	PAAD	TCGA	RRTVLEEIG	DEG_APCC_DBOX_1	31:39	Mutation altering degron motif	0.7329
p.R32Q	DO46657	PAAD	ICGC	RRTVLEEIG	DEG_APCC_DBOX_1	31:39	Mutation altering degron motif	0.7329
p.R32Q	DO41109	UCEC	ICGC	RRTVLEEIG	DEG_APCC_DBOX_1	31:39	Mutation altering degron motif	0.7329
p.R32Q	DO41133	UCEC	ICGC	RRTVLEEIG	DEG_APCC_DBOX_1	31:39	Mutation altering degron motif	0.7329
p.V68I	TCGA-AX-A06F	UCEC	TCGA	KPTASVKPV	DEG_SIAH_1	73:81	Mutation rewiring degron network	0.1944
p.V68I	DO41752	UCEC	ICGC	KPTASVKPV	DEG_SIAH_1	73:81	Mutation rewiring degron network	0.1944
p.V68I	SIDM00619	Thyroid Gland Carcinoma	GDSC	KPTASVKPV	DEG_SIAH_1	73:81	Mutation rewiring degron network	0.1944
p.V68I	ACH-002397	Thyroid Cancer	CCLE	KPTASVKPV	DEG_SIAH_1	73:81	Mutation rewiring degron network	0.1944
p.V68I	KMH-2	thyroid	COSMIC	KPTASVKPV	DEG_SIAH_1	73:81	Mutation rewiring degron network	0.1944
p.A87V	TCGA-BH-A0HF	BRCA	TCGA	KPTASVKPV	DEG_SIAH_1	73:81	Mutation rewiring degron network	0.1667
p.A87V	DO1749	BRCA	ICGC	KPTASVKPV	DEG_SIAH_1	73:81	Mutation rewiring degron network	0.1667
p.T66K	TCGA-DI-A1BU	UCEC	TCGA	KPTASVKPV	DEG_SIAH_1	73:81	Mutation rewiring degron network	0.1389
p.T66K	DO42023	UCEC	ICGC	KPTASVKPV	DEG_SIAH_1	73:81	Mutation rewiring degron network	0.1389
p.E84D	TCGA-ND-A4WC	UCS	TCGA	KPTASVKPV	DEG_SIAH_1	73:81	Mutation rewiring degron network	0.25
p.R83C	DO10092	COAD	ICGC	KPTASVKPV	DEG_SIAH_1	73:81	Mutation rewiring degron network	0.2778
p.R83C	DO222501	COCA	ICGC	KPTASVKPV	DEG_SIAH_1	73:81	Mutation rewiring degron network	0.2778
p.R85C	DO7776	COAD	ICGC	KPTASVKPV	DEG_SIAH_1	73:81	Mutation blocking ubiquitination signal	0.6667
p.R85C	DO223658	PRAD	ICGC	KPTASVKPV	DEG_SIAH_1	73:81	Mutation blocking ubiquitination signal	0.6667
p.R85C	NCI-H630	large intestine	COSMIC	KPTASVKPV	DEG_SIAH_1	73:81	Mutation blocking ubiquitination signal	0.6667
p.W44L	DO229019	LICA	ICGC	RRTVLEEIG	DEG_APCC_DBOX_1	31:39	Mutation rewiring degron network	0.1944
p.Q48H	DO229026	LICA	ICGC	RRTVLEEIG	DEG_APCC_DBOX_1	31:39	Mutation rewiring degron network	0.0833
p.D90H	DO230961	LUSC	ICGC	KPTASVKPV	DEG_SIAH_1	73:81	Mutation rewiring degron network	0.0833
p.V68D	SIDM00619	Thyroid Gland Carcinoma	GDSC	KPTASVKPV	DEG_SIAH_1	73:81	Mutation rewiring degron network	0.1944
p.V68D	ACH-002397	Thyroid Cancer	CCLE	KPTASVKPV	DEG_SIAH_1	73:81	Mutation rewiring degron network	0.1944
p.V68D	KMH-2	thyroid	COSMIC	KPTASVKPV	DEG_SIAH_1	73:81	Mutation rewiring degron network	0.1944
p.T75I	SIDM00886	B-Cell Non-Hodgkin's Lymphoma	GDSC	KPTASVKPV	DEG_SIAH_1	73:81	Mutation altering degron motif	0.5966
p.T75I	ACH-000334	Lymphoma	CCLE	KPTASVKPV	DEG_SIAH_1	73:81	Mutation altering degron motif	0.5966
p.T75I	DB	haematopoietic and lymphoid tissue	COSMIC	KPTASVKPV	DEG_SIAH_1	73:81	Mutation altering degron motif	0.5966
p.T33A	SIDM00278	Esophageal Squamous Cell Carcinoma	GDSC	RRTVLEEIG	DEG_APCC_DBOX_1	31:39	Mutation altering degron motif	0.6028
p.T33A	EC-GI-10	oesophagus	COSMIC	RRTVLEEIG	DEG_APCC_DBOX_1	31:39	Mutation altering degron motif	0.6028
p.G90V	SIDM01336	Glioblastoma	GDSC	KPTASVKPV	DEG_SIAH_1	73:81	Mutation rewiring degron network	0.0833
p.E37K	NCI-H2135	lung	COSMIC	RRTVLEEIG	DEG_APCC_DBOX_1	31:39	Mutation altering degron motif	0.591
p.R83H	OCUB-M	breast	COSMIC	KPTASVKPV	DEG_SIAH_1	73:81	Mutation rewiring degron network	0.2778

Kaplan plot for CCNB2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CCNB2

UniProt ID: O95067

Entrez ID: 9133

Protein name: G2/mitotic-specific cyclin-B2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CCNB2 in