DegronMD

Uniprot ID: O95067

Source protein: G2/mitotic-specific cyclin-B2

Source gene: CCNB2

Class: DEG_APCC_DBOX_1

Location: 31:39

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7148

ASA_SCORE: 71.1333

COIL: 0.4311

CONS_SCORE: 0.4158

DSS_SCORE: 0.3735

HELIX: 0.4829

FCONS_SCORE: 1.6196

RIG_SCORE: 0.8374

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R31M	TCGA-77-7142	LUSC	TCGA	RRTVLEEIG	DEG_APCC_DBOX_1	0.7521
p.R31M	DO26462	LUSC	ICGC	RRTVLEEIG	DEG_APCC_DBOX_1	0.7521
p.R32Q	TCGA-A5-A0GP	UCEC	TCGA	RRTVLEEIG	DEG_APCC_DBOX_1	0.7329
p.R32Q	TCGA-AX-A0J0	UCEC	TCGA	RRTVLEEIG	DEG_APCC_DBOX_1	0.7329
p.R32Q	TCGA-IB-7651	PAAD	TCGA	RRTVLEEIG	DEG_APCC_DBOX_1	0.7329
p.R32Q	DO46657	PAAD	ICGC	RRTVLEEIG	DEG_APCC_DBOX_1	0.7329
p.R32Q	DO41109	UCEC	ICGC	RRTVLEEIG	DEG_APCC_DBOX_1	0.7329
p.R32Q	DO41133	UCEC	ICGC	RRTVLEEIG	DEG_APCC_DBOX_1	0.7329
p.W44L	DO229019	LICA	ICGC	RRTVLEEIG	DEG_APCC_DBOX_1	0.1944
p.Q48H	DO229026	LICA	ICGC	RRTVLEEIG	DEG_APCC_DBOX_1	0.0833
p.T33A	SIDM00278	Esophageal Squamous Cell Carcinoma	GDSC	RRTVLEEIG	DEG_APCC_DBOX_1	0.6028
p.T33A	EC-GI-10	oesophagus	COSMIC	RRTVLEEIG	DEG_APCC_DBOX_1	0.6028
p.E37K	NCI-H2135	lung	COSMIC	RRTVLEEIG	DEG_APCC_DBOX_1	0.591

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95067	G2/mitotic-specific cyclin-B2	DEG_APCC_DBOX_1	31:39	RRTVLEEIG	APC,CDC20,FZR1	0.7148	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons