DegronMD

Uniprot ID: Q9Y4B4

Source protein: Helicase ARIP4

Source gene: RAD54L2

Class: DEG_SIAH_1

Location: 1018:1026

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9988

ASA_SCORE: 80.5889

COIL: 0.8357

CONS_SCORE: 0.3191

DSS_SCORE: 0.5912

HELIX: 0.0987

FCONS_SCORE: 1.1012

RIG_SCORE: 0.7068

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1032S	TCGA-06-0151	GBM	TCGA	KPVASVRPV	DEG_SIAH_1	0.1667
p.P1032S	DO44406	GBM	ICGC	KPVASVRPV	DEG_SIAH_1	0.1667
p.R1024L	TCGA-64-1679	LUAD	TCGA	KPVASVRPV	DEG_SIAH_1	0.7316
p.R1024L	DO26200	LUAD	ICGC	KPVASVRPV	DEG_SIAH_1	0.7316
p.K1014N	TCGA-A3-A6NL	KIRC	TCGA	KPVASVRPV	DEG_SIAH_1	0.3333
p.K1014N	DO50458	KIRC	ICGC	KPVASVRPV	DEG_SIAH_1	0.3333
p.V1026M	TCGA-HJ-7597	STAD	TCGA	KPVASVRPV	DEG_SIAH_1	0.6097
p.V1026M	DO38195	STAD	ICGC	KPVASVRPV	DEG_SIAH_1	0.6097
p.L1013F	TCGA-IE-A6BZ	SARC	TCGA	KPVASVRPV	DEG_SIAH_1	0.1944
p.L1013F	DO220159	SARC	ICGC	KPVASVRPV	DEG_SIAH_1	0.1944
p.R1024C	TCGA-W3-AA1V	SKCM	TCGA	KPVASVRPV	DEG_SIAH_1	0.719
p.R1024C	DO51276	SKCM	ICGC	KPVASVRPV	DEG_SIAH_1	0.719
p.R1024C	SIDM00534	Colorectal Carcinoma	GDSC	KPVASVRPV	DEG_SIAH_1	0.719
p.R1024C	ACH-000986	Colon/Colorectal Cancer	CCLE	KPVASVRPV	DEG_SIAH_1	0.719
p.R1024C	HT-115	large_intestine	COSMIC	KPVASVRPV	DEG_SIAH_1	0.719
p.R1036Q	DO222798	COCA	ICGC	KPVASVRPV	DEG_SIAH_1	0.0556
p.R1036Q	SIDM00217	Colorectal Carcinoma	GDSC	KPVASVRPV	DEG_SIAH_1	0.0556
p.R1036Q	ACH-000999	Colon/Colorectal Cancer	CCLE	KPVASVRPV	DEG_SIAH_1	0.0556
p.R1036Q	SNU-1040	large_intestine	COSMIC	KPVASVRPV	DEG_SIAH_1	0.0556
p.S1028F	SIDM00080	Melanoma	GDSC	KPVASVRPV	DEG_SIAH_1	0.2778
p.S1028F	SIDM00317	Kidney Carcinoma	GDSC	KPVASVRPV	DEG_SIAH_1	0.2778
p.S1028F	ACH-000730	Skin Cancer	CCLE	KPVASVRPV	DEG_SIAH_1	0.2778
p.S1028F	VMRC-RCZ	kidney	COSMIC	KPVASVRPV	DEG_SIAH_1	0.2778
p.S1028F	SK-MEL-5	skin	COSMIC	KPVASVRPV	DEG_SIAH_1	0.2778
p.R1036W	SIDM01451	Pancreatic Carcinoma	GDSC	KPVASVRPV	DEG_SIAH_1	0.0556
p.R1036W	ACH-000933	Pancreatic Cancer	CCLE	KPVASVRPV	DEG_SIAH_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y4B4	Helicase ARIP4	DEG_SIAH_1	1018:1026	KPVASVRPV	SIAH1,SIAH2,SIAH3	0.9988	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KPVASVRPV

Degron related mutations and impact score

Drug responses associated with RAD54L2 mutations

All proteins holding degron of KPVASVRPV