DegronMD - Q9Y4B4(RAD54L2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P1032S	TCGA-06-0151	GBM	TCGA	KPVASVRPV	DEG_SIAH_1	1018:1026	Mutation rewiring degron network	0.1667
p.P1032S	DO44406	GBM	ICGC	KPVASVRPV	DEG_SIAH_1	1018:1026	Mutation rewiring degron network	0.1667
p.R1024L	TCGA-64-1679	LUAD	TCGA	KPVASVRPV	DEG_SIAH_1	1018:1026	Mutation altering degron motif	0.7316
p.R1024L	DO26200	LUAD	ICGC	KPVASVRPV	DEG_SIAH_1	1018:1026	Mutation altering degron motif	0.7316
p.K1014N	TCGA-A3-A6NL	KIRC	TCGA	KPVASVRPV	DEG_SIAH_1	1018:1026	Mutation substituting flanking lysine	0.3333
p.K1014N	DO50458	KIRC	ICGC	KPVASVRPV	DEG_SIAH_1	1018:1026	Mutation substituting flanking lysine	0.3333
p.G1314W	TCGA-BF-A1Q0	SKCM	TCGA	LTTPFTS	DEG_SCF_FBW7_1	1305:1311	Mutation rewiring degron network	0.25
p.G1314W	DO47374	SKCM	ICGC	LTTPFTS	DEG_SCF_FBW7_1	1305:1311	Mutation rewiring degron network	0.25
p.V1299I	TCGA-DF-A2KU	UCEC	TCGA	LTTPFTS	DEG_SCF_FBW7_1	1305:1311	Mutation rewiring degron network	0.1667
p.V1299I	DO35206	PACA	ICGC	LTTPFTS	DEG_SCF_FBW7_1	1305:1311	Mutation rewiring degron network	0.1667
p.V1299I	DO223286	UCEC	ICGC	LTTPFTS	DEG_SCF_FBW7_1	1305:1311	Mutation rewiring degron network	0.1667
p.V1299I	SIDM00850	Gastric Carcinoma	GDSC	LTTPFTS	DEG_SCF_FBW7_1	1305:1311	Mutation rewiring degron network	0.1667
p.V1299I	ACH-000880	Gastric Cancer	CCLE	LTTPFTS	DEG_SCF_FBW7_1	1305:1311	Mutation rewiring degron network	0.1667
p.V1299I	AGS	stomach	COSMIC	LTTPFTS	DEG_SCF_FBW7_1	1305:1311	Mutation rewiring degron network	0.1667
p.V1026M	TCGA-HJ-7597	STAD	TCGA	KPVASVRPV	DEG_SIAH_1	1018:1026	Mutation altering degron motif	0.6097
p.V1026M	DO38195	STAD	ICGC	KPVASVRPV	DEG_SIAH_1	1018:1026	Mutation altering degron motif	0.6097
p.L1013F	TCGA-IE-A6BZ	SARC	TCGA	KPVASVRPV	DEG_SIAH_1	1018:1026	Mutation rewiring degron network	0.1944
p.L1013F	DO220159	SARC	ICGC	KPVASVRPV	DEG_SIAH_1	1018:1026	Mutation rewiring degron network	0.1944
p.R1024C	TCGA-W3-AA1V	SKCM	TCGA	KPVASVRPV	DEG_SIAH_1	1018:1026	Mutation altering degron motif	0.719
p.R1024C	DO51276	SKCM	ICGC	KPVASVRPV	DEG_SIAH_1	1018:1026	Mutation altering degron motif	0.719
p.R1024C	SIDM00534	Colorectal Carcinoma	GDSC	KPVASVRPV	DEG_SIAH_1	1018:1026	Mutation altering degron motif	0.719
p.R1024C	ACH-000986	Colon/Colorectal Cancer	CCLE	KPVASVRPV	DEG_SIAH_1	1018:1026	Mutation altering degron motif	0.719
p.R1024C	HT-115	large intestine	COSMIC	KPVASVRPV	DEG_SIAH_1	1018:1026	Mutation altering degron motif	0.719
p.M1296I	DO48384	BLCA	ICGC	LTTPFTS	DEG_SCF_FBW7_1	1305:1311	Mutation rewiring degron network	0.0833
p.R1036Q	DO222798	COCA	ICGC	KPVASVRPV	DEG_SIAH_1	1018:1026	Mutation rewiring degron network	0.0556
p.R1036Q	SIDM00217	Colorectal Carcinoma	GDSC	KPVASVRPV	DEG_SIAH_1	1018:1026	Mutation rewiring degron network	0.0556
p.R1036Q	ACH-000999	Colon/Colorectal Cancer	CCLE	KPVASVRPV	DEG_SIAH_1	1018:1026	Mutation rewiring degron network	0.0556
p.R1036Q	SNU-1040	large intestine	COSMIC	KPVASVRPV	DEG_SIAH_1	1018:1026	Mutation rewiring degron network	0.0556
p.A1313S	DO229028	LICA	ICGC	LTTPFTS	DEG_SCF_FBW7_1	1305:1311	Mutation rewiring degron network	0.2778
p.S1028F	SIDM00080	Melanoma	GDSC	KPVASVRPV	DEG_SIAH_1	1018:1026	Mutation rewiring degron network	0.2778
p.S1028F	SIDM00317	Kidney Carcinoma	GDSC	KPVASVRPV	DEG_SIAH_1	1018:1026	Mutation rewiring degron network	0.2778
p.S1028F	ACH-000730	Skin Cancer	CCLE	KPVASVRPV	DEG_SIAH_1	1018:1026	Mutation rewiring degron network	0.2778
p.S1028F	VMRC-RCZ	kidney	COSMIC	KPVASVRPV	DEG_SIAH_1	1018:1026	Mutation rewiring degron network	0.2778
p.S1028F	SK-MEL-5	skin	COSMIC	KPVASVRPV	DEG_SIAH_1	1018:1026	Mutation rewiring degron network	0.2778
p.R1036W	SIDM01451	Pancreatic Carcinoma	GDSC	KPVASVRPV	DEG_SIAH_1	1018:1026	Mutation rewiring degron network	0.0556
p.R1036W	ACH-000933	Pancreatic Cancer	CCLE	KPVASVRPV	DEG_SIAH_1	1018:1026	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RAD54L2

UniProt ID: Q9Y4B4

Entrez ID: 23132

Protein name: Helicase ARIP4 (EC 3.6.4.12) (Androgen receptor-interacting protein 4) (RAD54-like protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RAD54L2 in