DegronMD

Uniprot ID: Q9Y4B4

Source protein: Helicase ARIP4

Source gene: RAD54L2

Class: DEG_SCF_FBW7_1

Location: 1305:1311

E3 ligase: FBXW7

DEGRON score: 0.9655

ASA_SCORE: 69.8143

COIL: 0.859

CONS_SCORE: 0.292

DSS_SCORE: 0.4115

HELIX: 0.0877

FCONS_SCORE: 0.9695

RIG_SCORE: 0.7655

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1314W	TCGA-BF-A1Q0	SKCM	TCGA	LTTPFTS	DEG_SCF_FBW7_1	0.25
p.G1314W	DO47374	SKCM	ICGC	LTTPFTS	DEG_SCF_FBW7_1	0.25
p.V1299I	TCGA-DF-A2KU	UCEC	TCGA	LTTPFTS	DEG_SCF_FBW7_1	0.1667
p.V1299I	DO35206	PACA	ICGC	LTTPFTS	DEG_SCF_FBW7_1	0.1667
p.V1299I	DO223286	UCEC	ICGC	LTTPFTS	DEG_SCF_FBW7_1	0.1667
p.V1299I	SIDM00850	Gastric Carcinoma	GDSC	LTTPFTS	DEG_SCF_FBW7_1	0.1667
p.V1299I	ACH-000880	Gastric Cancer	CCLE	LTTPFTS	DEG_SCF_FBW7_1	0.1667
p.V1299I	AGS	stomach	COSMIC	LTTPFTS	DEG_SCF_FBW7_1	0.1667
p.M1296I	DO48384	BLCA	ICGC	LTTPFTS	DEG_SCF_FBW7_1	0.0833
p.A1313S	DO229028	LICA	ICGC	LTTPFTS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y4B4	Helicase ARIP4	DEG_SCF_FBW7_1	1305:1311	LTTPFTS	FBXW7	0.9655	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons