DegronMD

Uniprot ID: Q9Y365

Source protein: START domain-containing protein 10

Source gene: STARD10

Class: LIG_APCC_ABBAyCdc20_2

Location: 234:240

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9964

ASA_SCORE: 72.7857

COIL: 0.8016

CONS_SCORE: 0.705

DSS_SCORE: 0.384

HELIX: 0.1504

FCONS_SCORE: 1.1503

RIG_SCORE: 0.7285

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E224K	TCGA-B5-A0JY	UCEC	TCGA	KPWLHPE	LIG_APCC_ABBAyCdc20_2	0.0556
p.E224K	TCGA-EY-A215	UCEC	TCGA	KPWLHPE	LIG_APCC_ABBAyCdc20_2	0.0556
p.E224K	DO8938	COAD	ICGC	KPWLHPE	LIG_APCC_ABBAyCdc20_2	0.0556
p.E224K	DO223053	ESCA	ICGC	KPWLHPE	LIG_APCC_ABBAyCdc20_2	0.0556
p.E224K	DO232761	PBCA	ICGC	KPWLHPE	LIG_APCC_ABBAyCdc20_2	0.0556
p.E224K	DO43041	UCEC	ICGC	KPWLHPE	LIG_APCC_ABBAyCdc20_2	0.0556
p.E224K	DO42665	UCEC	ICGC	KPWLHPE	LIG_APCC_ABBAyCdc20_2	0.0556
p.P245S	TCGA-D3-A8GB	SKCM	TCGA	KPWLHPE	LIG_APCC_ABBAyCdc20_2	0.1944
p.R229Q	DO222864	COCA	ICGC	KPWLHPE	LIG_APCC_ABBAyCdc20_2	0.1944
p.D240E	DO228986	LICA	ICGC	KPWLHPE	LIG_APCC_ABBAyCdc20_2	0.6758
p.A233E	DO229037	LICA	ICGC	KPWLHPE	LIG_APCC_ABBAyCdc20_2	0.3056
p.L237P	SIDM00070	B-Cell Non-Hodgkin's Lymphoma	GDSC	KPWLHPE	LIG_APCC_ABBAyCdc20_2	0.7582
p.L237P	ACH-002393	Lymphoma	CCLE	KPWLHPE	LIG_APCC_ABBAyCdc20_2	0.7582
p.L237P	CRO-AP3	NS	COSMIC	KPWLHPE	LIG_APCC_ABBAyCdc20_2	0.7582
p.L230Q	SIDM01609	Endometrial Carcinoma	GDSC	KPWLHPE	LIG_APCC_ABBAyCdc20_2	0.2222
p.L230Q	ACH-000972	Endometrial/Uterine Cancer	CCLE	KPWLHPE	LIG_APCC_ABBAyCdc20_2	0.2222
p.F233L	ACH-001409	Bladder Cancer	CCLE	KPWLHPE	LIG_APCC_ABBAyCdc20_2	0.3056
p.D235N	SW684	soft_tissue	COSMIC	KPWLHPE	LIG_APCC_ABBAyCdc20_2	0.6932
p.D239E	NCI-H2135	lung	COSMIC	KPWLHPE	LIG_APCC_ABBAyCdc20_2	0.6758

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y365	START domain-containing protein 10	LIG_APCC_ABBAyCdc20_2	234:240	KPWLHPE	APC,CDC20,FZR1	0.9964	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons