DegronMD

Uniprot ID: P43378

Source protein: Tyrosine-protein phosphatase non-receptor type 9

Source gene: PTPN9

Class: LIG_APCC_ABBAyCdc20_2

Location: 300:306

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9813

ASA_SCORE: 69.4143

COIL: 0.4301

CONS_SCORE: 0.4073

DSS_SCORE: 0.3295

HELIX: 0.5536

FCONS_SCORE: 1.139

RIG_SCORE: 0.8045

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R298T	TCGA-50-6591	LUAD	TCGA	KQGIYEE	LIG_APCC_ABBAyCdc20_2	0.2778
p.R298T	DO23702	LUAD	ICGC	KQGIYEE	LIG_APCC_ABBAyCdc20_2	0.2778
p.R311H	TCGA-AA-A022	COAD	TCGA	KQGIYEE	LIG_APCC_ABBAyCdc20_2	0.1944
p.R311H	DO10647	COAD	ICGC	KQGIYEE	LIG_APCC_ABBAyCdc20_2	0.1944
p.R311C	TCGA-AG-A002	READ	TCGA	KQGIYEE	LIG_APCC_ABBAyCdc20_2	0.1944
p.R311C	SIDM00101	Mesothelioma	GDSC	KQGIYEE	LIG_APCC_ABBAyCdc20_2	0.1944
p.R311C	ACH-002126	Lung Cancer	CCLE	KQGIYEE	LIG_APCC_ABBAyCdc20_2	0.1944
p.R311C	H2591	pleura	COSMIC	KQGIYEE	LIG_APCC_ABBAyCdc20_2	0.1944
p.R312C	TCGA-AP-A0LM	UCEC	TCGA	KQGIYEE	LIG_APCC_ABBAyCdc20_2	0.1667
p.R312C	DO43306	UCEC	ICGC	KQGIYEE	LIG_APCC_ABBAyCdc20_2	0.1667
p.E313K	TCGA-B5-A11R	UCEC	TCGA	KQGIYEE	LIG_APCC_ABBAyCdc20_2	0.1389
p.E313K	DO43787	UCEC	ICGC	KQGIYEE	LIG_APCC_ABBAyCdc20_2	0.1389
p.D309H	TCGA-DK-A1A5	BLCA	TCGA	KQGIYEE	LIG_APCC_ABBAyCdc20_2	0.25
p.D309H	DO477	BLCA	ICGC	KQGIYEE	LIG_APCC_ABBAyCdc20_2	0.25
p.D309H	ACH-001568	Skin Cancer	CCLE	KQGIYEE	LIG_APCC_ABBAyCdc20_2	0.25
p.V295I	TCGA-DU-6392	LGG	TCGA	KQGIYEE	LIG_APCC_ABBAyCdc20_2	0.1944
p.V295I	DO22237	LGG	ICGC	KQGIYEE	LIG_APCC_ABBAyCdc20_2	0.1944
p.V295A	TCGA-L5-A8NJ	ESCA	TCGA	KQGIYEE	LIG_APCC_ABBAyCdc20_2	0.1944
p.G302R	TCGA-S5-A6DX	BLCA	TCGA	KQGIYEE	LIG_APCC_ABBAyCdc20_2	0.6457
p.G302R	DO51903	BLCA	ICGC	KQGIYEE	LIG_APCC_ABBAyCdc20_2	0.6457
p.D293E	DO229035	LICA	ICGC	KQGIYEE	LIG_APCC_ABBAyCdc20_2	0.1389
p.R312H	SIDM00429	B-Lymphoblastic Leukemia	GDSC	KQGIYEE	LIG_APCC_ABBAyCdc20_2	0.1667
p.R301C	H2591	pleura	COSMIC	KQGIYEE	LIG_APCC_ABBAyCdc20_2	0.8301
p.S312P	EN	endometrium	COSMIC	KQGIYEE	LIG_APCC_ABBAyCdc20_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P43378	Tyrosine-protein phosphatase non-receptor type 9	LIG_APCC_ABBAyCdc20_2	300:306	KQGIYEE	APC,CDC20,FZR1	0.9813	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KQGIYEE

Degron related mutations and impact score

Drug responses associated with PTPN9 mutations

All proteins holding degron of KQGIYEE