DegronMD - P43378(PTPN9)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R298T	TCGA-50-6591	LUAD	TCGA	KQGIYEE	LIG_APCC_ABBAyCdc20_2	300:306	Mutation rewiring degron network	0.2778
p.R298T	DO23702	LUAD	ICGC	KQGIYEE	LIG_APCC_ABBAyCdc20_2	300:306	Mutation rewiring degron network	0.2778
p.E90D	TCGA-50-6593	LUAD	TCGA	LKPHEE	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.1944
p.E90D	DO24100	LUAD	ICGC	LKPHEE	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.1944
p.R311H	TCGA-AA-A022	COAD	TCGA	KQGIYEE	LIG_APCC_ABBAyCdc20_2	300:306	Mutation rewiring degron network	0.1944
p.R311H	DO10647	COAD	ICGC	KQGIYEE	LIG_APCC_ABBAyCdc20_2	300:306	Mutation rewiring degron network	0.1944
p.R311C	TCGA-AG-A002	READ	TCGA	KQGIYEE	LIG_APCC_ABBAyCdc20_2	300:306	Mutation rewiring degron network	0.1944
p.R311C	SIDM00101	Mesothelioma	GDSC	KQGIYEE	LIG_APCC_ABBAyCdc20_2	300:306	Mutation rewiring degron network	0.1944
p.R311C	ACH-002126	Lung Cancer	CCLE	KQGIYEE	LIG_APCC_ABBAyCdc20_2	300:306	Mutation rewiring degron network	0.1944
p.R311C	H2591	pleura	COSMIC	KQGIYEE	LIG_APCC_ABBAyCdc20_2	300:306	Mutation rewiring degron network	0.1944
p.R312C	TCGA-AP-A0LM	UCEC	TCGA	KQGIYEE	LIG_APCC_ABBAyCdc20_2	300:306	Mutation rewiring degron network	0.1667
p.R312C	DO43306	UCEC	ICGC	KQGIYEE	LIG_APCC_ABBAyCdc20_2	300:306	Mutation rewiring degron network	0.1667
p.E313K	TCGA-B5-A11R	UCEC	TCGA	KQGIYEE	LIG_APCC_ABBAyCdc20_2	300:306	Mutation rewiring degron network	0.1389
p.E313K	DO43787	UCEC	ICGC	KQGIYEE	LIG_APCC_ABBAyCdc20_2	300:306	Mutation rewiring degron network	0.1389
p.R88C	TCGA-DA-A1IC	SKCM	TCGA	LKPHEE	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.25
p.R88C	TCGA-EE-A29E	SKCM	TCGA	LKPHEE	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.25
p.R88C	DO37831	SKCM	ICGC	LKPHEE	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.25
p.R88C	DO37430	SKCM	ICGC	LKPHEE	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.25
p.D309H	TCGA-DK-A1A5	BLCA	TCGA	KQGIYEE	LIG_APCC_ABBAyCdc20_2	300:306	Mutation rewiring degron network	0.25
p.D309H	DO477	BLCA	ICGC	KQGIYEE	LIG_APCC_ABBAyCdc20_2	300:306	Mutation rewiring degron network	0.25
p.D309H	ACH-001568	Skin Cancer	CCLE	KQGIYEE	LIG_APCC_ABBAyCdc20_2	300:306	Mutation rewiring degron network	0.25
p.V295I	TCGA-DU-6392	LGG	TCGA	KQGIYEE	LIG_APCC_ABBAyCdc20_2	300:306	Mutation rewiring degron network	0.1944
p.V295I	DO22237	LGG	ICGC	KQGIYEE	LIG_APCC_ABBAyCdc20_2	300:306	Mutation rewiring degron network	0.1944
p.H83N	TCGA-DU-7294	LGG	TCGA	LKPHEE	LIG_APCC_ABBA_1	80:85	Mutation altering degron motif	0.7423
p.H83N	DO22333	LGG	ICGC	LKPHEE	LIG_APCC_ABBA_1	80:85	Mutation altering degron motif	0.7423
p.G94E	TCGA-HC-8264	PRAD	TCGA	LKPHEE	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.0833
p.G94E	DO49820	PRAD	ICGC	LKPHEE	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.0833
p.V295A	TCGA-L5-A8NJ	ESCA	TCGA	KQGIYEE	LIG_APCC_ABBAyCdc20_2	300:306	Mutation rewiring degron network	0.1944
p.G302R	TCGA-S5-A6DX	BLCA	TCGA	KQGIYEE	LIG_APCC_ABBAyCdc20_2	300:306	Mutation altering degron motif	0.6457
p.G302R	DO51903	BLCA	ICGC	KQGIYEE	LIG_APCC_ABBAyCdc20_2	300:306	Mutation altering degron motif	0.6457
p.D293E	DO229035	LICA	ICGC	KQGIYEE	LIG_APCC_ABBAyCdc20_2	300:306	Mutation rewiring degron network	0.1389
p.S89Y	DO45141	LIRI	ICGC	LKPHEE	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.2222
p.P86L	DO49433	PACA	ICGC	LKPHEE	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.3056
p.R72Q	SIDM00775	Non-Small Cell Lung Carcinoma	GDSC	LKPHEE	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.1111
p.R72Q	ACH-000785	Lung Cancer	CCLE	LKPHEE	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.1111
p.R72Q	NCI-H2126	lung	COSMIC	LKPHEE	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.1111
p.R312H	SIDM00429	B-Lymphoblastic Leukemia	GDSC	KQGIYEE	LIG_APCC_ABBAyCdc20_2	300:306	Mutation rewiring degron network	0.1667
p.L92P	ACH-001610	Brain Cancer	CCLE	LKPHEE	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.1389
p.R92W	LS-411N	large intestine	COSMIC	LKPHEE	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.1389
p.R301C	H2591	pleura	COSMIC	KQGIYEE	LIG_APCC_ABBAyCdc20_2	300:306	Mutation altering degron motif	0.8301
p.S312P	EN	endometrium	COSMIC	KQGIYEE	LIG_APCC_ABBAyCdc20_2	300:306	Mutation rewiring degron network	0.1667

Kaplan plot for PTPN9 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PTPN9

UniProt ID: P43378

Entrez ID: 5780

Protein name: Tyrosine-protein phosphatase non-receptor type 9 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG2) (PTPase MEG2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PTPN9 in