DegronMD - P43378(PTPN9)

FUNCTION: Protein-tyrosine phosphatase that could participate in the transfer of hydrophobic ligands or in functions of the Golgi apparatus. {ECO:0000269|PubMed:19167335}.

GO - Biological processes (BP): negative regulation of neuron projection development [GO:0010977]; peptidyl-tyrosine dephosphorylation [GO:0035335]; positive regulation of protein localization to plasma membrane [GO:1903078]; protein dephosphorylation [GO:0006470]

GO - Molecular function (MF): non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein tyrosine phosphatase activity [GO:0004725]

GO - Cellular component (CC): cytoplasm [GO:0005737]; neuron projection terminus [GO:0044306]; nucleoplasm [GO:0005654]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R301C	H2591	pleura	COSMIC	KQGIYEE	LIG_APCC_ABBAyCdc20_2	300:306	Mutation altering degron motif	0.8301
p.H83N	TCGA-DU-7294	LGG	TCGA	LKPHEE	LIG_APCC_ABBA_1	80:85	Mutation altering degron motif	0.7423
p.H83N	DO22333	LGG	ICGC	LKPHEE	LIG_APCC_ABBA_1	80:85	Mutation altering degron motif	0.7423
p.G302R	TCGA-S5-A6DX	BLCA	TCGA	KQGIYEE	LIG_APCC_ABBAyCdc20_2	300:306	Mutation altering degron motif	0.6457
p.G302R	DO51903	BLCA	ICGC	KQGIYEE	LIG_APCC_ABBAyCdc20_2	300:306	Mutation altering degron motif	0.6457
p.P86L	DO49433	PACA	ICGC	LKPHEE	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.3056
p.R298T	TCGA-50-6591	LUAD	TCGA	KQGIYEE	LIG_APCC_ABBAyCdc20_2	300:306	Mutation rewiring degron network	0.2778
p.R298T	DO23702	LUAD	ICGC	KQGIYEE	LIG_APCC_ABBAyCdc20_2	300:306	Mutation rewiring degron network	0.2778
p.R88C	TCGA-DA-A1IC	SKCM	TCGA	LKPHEE	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.25
p.R88C	TCGA-EE-A29E	SKCM	TCGA	LKPHEE	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.25
p.R88C	DO37831	SKCM	ICGC	LKPHEE	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.25
p.R88C	DO37430	SKCM	ICGC	LKPHEE	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.25
p.D309H	TCGA-DK-A1A5	BLCA	TCGA	KQGIYEE	LIG_APCC_ABBAyCdc20_2	300:306	Mutation rewiring degron network	0.25
p.D309H	DO477	BLCA	ICGC	KQGIYEE	LIG_APCC_ABBAyCdc20_2	300:306	Mutation rewiring degron network	0.25
p.D309H	ACH-001568	Skin Cancer	CCLE	KQGIYEE	LIG_APCC_ABBAyCdc20_2	300:306	Mutation rewiring degron network	0.25
p.S89Y	DO45141	LIRI	ICGC	LKPHEE	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.2222
p.E90D	TCGA-50-6593	LUAD	TCGA	LKPHEE	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.1944
p.E90D	DO24100	LUAD	ICGC	LKPHEE	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.1944
p.R311H	TCGA-AA-A022	COAD	TCGA	KQGIYEE	LIG_APCC_ABBAyCdc20_2	300:306	Mutation rewiring degron network	0.1944
p.R311H	DO10647	COAD	ICGC	KQGIYEE	LIG_APCC_ABBAyCdc20_2	300:306	Mutation rewiring degron network	0.1944

Showing 1 to 20 of 41 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

PTPN9

UniProt ID: P43378

Entrez ID: 5780

Protein name: Tyrosine-protein phosphatase non-receptor type 9 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG2) (PTPase MEG2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PTPN9 in