DegronMD

Uniprot ID: P43378

Source protein: Tyrosine-protein phosphatase non-receptor type 9

Source gene: PTPN9

Class: LIG_APCC_ABBA_1

Location: 80:85

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9163

ASA_SCORE: 83.4833

COIL: 0.8173

CONS_SCORE: 0.3988

DSS_SCORE: 0.3559

HELIX: 0.1678

FCONS_SCORE: 1.0234

RIG_SCORE: 0.7586

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E90D	TCGA-50-6593	LUAD	TCGA	LKPHEE	LIG_APCC_ABBA_1	0.1944
p.E90D	DO24100	LUAD	ICGC	LKPHEE	LIG_APCC_ABBA_1	0.1944
p.R88C	TCGA-DA-A1IC	SKCM	TCGA	LKPHEE	LIG_APCC_ABBA_1	0.25
p.R88C	TCGA-EE-A29E	SKCM	TCGA	LKPHEE	LIG_APCC_ABBA_1	0.25
p.R88C	DO37831	SKCM	ICGC	LKPHEE	LIG_APCC_ABBA_1	0.25
p.R88C	DO37430	SKCM	ICGC	LKPHEE	LIG_APCC_ABBA_1	0.25
p.H83N	TCGA-DU-7294	LGG	TCGA	LKPHEE	LIG_APCC_ABBA_1	0.7423
p.H83N	DO22333	LGG	ICGC	LKPHEE	LIG_APCC_ABBA_1	0.7423
p.G94E	TCGA-HC-8264	PRAD	TCGA	LKPHEE	LIG_APCC_ABBA_1	0.0833
p.G94E	DO49820	PRAD	ICGC	LKPHEE	LIG_APCC_ABBA_1	0.0833
p.S89Y	DO45141	LIRI	ICGC	LKPHEE	LIG_APCC_ABBA_1	0.2222
p.P86L	DO49433	PACA	ICGC	LKPHEE	LIG_APCC_ABBA_1	0.3056
p.R72Q	SIDM00775	Non-Small Cell Lung Carcinoma	GDSC	LKPHEE	LIG_APCC_ABBA_1	0.1111
p.R72Q	ACH-000785	Lung Cancer	CCLE	LKPHEE	LIG_APCC_ABBA_1	0.1111
p.R72Q	NCI-H2126	lung	COSMIC	LKPHEE	LIG_APCC_ABBA_1	0.1111
p.L92P	ACH-001610	Brain Cancer	CCLE	LKPHEE	LIG_APCC_ABBA_1	0.1389
p.R92W	LS-411N	large_intestine	COSMIC	LKPHEE	LIG_APCC_ABBA_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P43378	Tyrosine-protein phosphatase non-receptor type 9	LIG_APCC_ABBA_1	80:85	LKPHEE	APC,CDC20,FZR1	0.9163	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons