DegronMD

Uniprot ID: Q9BZE4

Source protein: GTP-binding protein 4

Source gene: GTPBP4

Class: DEG_APCC_DBOX_1

Location: 130:138

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6247

ASA_SCORE: 67.5667

COIL: 0.2692

CONS_SCORE: 0.5478

DSS_SCORE: 0.117

HELIX: 0.7214

FCONS_SCORE: 1.2695

RIG_SCORE: 0.8444

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R131C	TCGA-2W-A8YY	CESC	TCGA	KRAALGRMC	DEG_APCC_DBOX_1	0.8301
p.R125H	TCGA-AG-3731	READ	TCGA	KRAALGRMC	DEG_APCC_DBOX_1	0.1944
p.R125H	SIDM00487	Colorectal Carcinoma	GDSC	KRAALGRMC	DEG_APCC_DBOX_1	0.1944
p.R125H	ACH-000963	Colon/Colorectal Cancer	CCLE	KRAALGRMC	DEG_APCC_DBOX_1	0.1944
p.R125H	CCK-81	large_intestine	COSMIC	KRAALGRMC	DEG_APCC_DBOX_1	0.1944
p.R131H	TCGA-B5-A1MV	UCEC	TCGA	KRAALGRMC	DEG_APCC_DBOX_1	0.8244
p.R131H	SIDM00881	Breast Carcinoma	GDSC	KRAALGRMC	DEG_APCC_DBOX_1	0.8244
p.R131H	HCC1428	breast	COSMIC	KRAALGRMC	DEG_APCC_DBOX_1	0.8244
p.M137I	TCGA-CR-7404	HNSC	TCGA	KRAALGRMC	DEG_APCC_DBOX_1	0.6507
p.M137I	SIDM00720	Mesothelioma	GDSC	KRAALGRMC	DEG_APCC_DBOX_1	0.6507
p.M137I	ACH-000648	Lung Cancer	CCLE	KRAALGRMC	DEG_APCC_DBOX_1	0.6507
p.M137I	NCI-H28	pleura	COSMIC	KRAALGRMC	DEG_APCC_DBOX_1	0.6507
p.R132C	DO227987	COCA	ICGC	KRAALGRMC	DEG_APCC_DBOX_1	0.8301
p.R132C	DO45127	LIRI	ICGC	KRAALGRMC	DEG_APCC_DBOX_1	0.8301
p.R132C	DO37406	SKCM	ICGC	KRAALGRMC	DEG_APCC_DBOX_1	0.8301
p.R132C	DO51301	SKCM	ICGC	KRAALGRMC	DEG_APCC_DBOX_1	0.8301
p.G146V	DO229015	LICA	ICGC	KRAALGRMC	DEG_APCC_DBOX_1	0.1111
p.L141F	DO231104	LUSC	ICGC	KRAALGRMC	DEG_APCC_DBOX_1	0.25
p.R132S	DO47509	SKCM	ICGC	KRAALGRMC	DEG_APCC_DBOX_1	0.7427
p.R132L	DO39756	THCA	ICGC	KRAALGRMC	DEG_APCC_DBOX_1	0.8428
p.K142N	SIDM00723	Non-Small Cell Lung Carcinoma	GDSC	KRAALGRMC	DEG_APCC_DBOX_1	0.6667
p.A132V	SIDM00680	Colorectal Carcinoma	GDSC	KRAALGRMC	DEG_APCC_DBOX_1	0.5825
p.A132V	ACH-000957	Colon/Colorectal Cancer	CCLE	KRAALGRMC	DEG_APCC_DBOX_1	0.5825
p.A132V	LS-180	large_intestine	COSMIC	KRAALGRMC	DEG_APCC_DBOX_1	0.5825
p.D121N	SIDM01588	Endometrial Carcinoma	GDSC	KRAALGRMC	DEG_APCC_DBOX_1	0.0833
p.D121N	ACH-000993	Endometrial/Uterine Cancer	CCLE	KRAALGRMC	DEG_APCC_DBOX_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KRAALGRMC

Degron related mutations and impact score

Drug responses associated with GTPBP4 mutations

All proteins holding degron of KRAALGRMC

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BZE4	GTP-binding protein 4	DEG_APCC_DBOX_1	130:138	KRAALGRMC	APC,CDC20,FZR1	0.6247	More...