DegronMD - Q9BZE4(GTPBP4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R131C	TCGA-2W-A8YY	CESC	TCGA	KRAALGRMC	DEG_APCC_DBOX_1	130:138	Mutation altering degron motif	0.8301
p.E152G	TCGA-2W-A8YY	CESC	TCGA	VRQHLSRLP	DEG_APCC_DBOX_1	154:162	Mutation rewiring degron network	0.2778
p.T168I	TCGA-60-2715	LUSC	TCGA	VRQHLSRLP	DEG_APCC_DBOX_1	154:162	Mutation blocking phosphorylation signal	0.6111
p.R125H	TCGA-AG-3731	READ	TCGA	KRAALGRMC	DEG_APCC_DBOX_1	130:138	Mutation rewiring degron network	0.1944
p.R125H	SIDM00487	Colorectal Carcinoma	GDSC	KRAALGRMC	DEG_APCC_DBOX_1	130:138	Mutation rewiring degron network	0.1944
p.R125H	ACH-000963	Colon/Colorectal Cancer	CCLE	KRAALGRMC	DEG_APCC_DBOX_1	130:138	Mutation rewiring degron network	0.1944
p.R125H	CCK-81	large intestine	COSMIC	KRAALGRMC	DEG_APCC_DBOX_1	130:138	Mutation rewiring degron network	0.1944
p.R131H	TCGA-B5-A1MV	UCEC	TCGA	KRAALGRMC	DEG_APCC_DBOX_1	130:138	Mutation altering degron motif	0.8244
p.R131H	SIDM00881	Breast Carcinoma	GDSC	KRAALGRMC	DEG_APCC_DBOX_1	130:138	Mutation altering degron motif	0.8244
p.R131H	HCC1428	breast	COSMIC	KRAALGRMC	DEG_APCC_DBOX_1	130:138	Mutation altering degron motif	0.8244
p.R155C	TCGA-BR-4184	STAD	TCGA	VRQHLSRLP	DEG_APCC_DBOX_1	154:162	Mutation altering degron motif	0.8301
p.R155C	SIDM01307	Colorectal Carcinoma	GDSC	VRQHLSRLP	DEG_APCC_DBOX_1	154:162	Mutation altering degron motif	0.8301
p.M137I	TCGA-CR-7404	HNSC	TCGA	KRAALGRMC	DEG_APCC_DBOX_1	130:138	Mutation altering degron motif	0.6507
p.M137I	SIDM00720	Mesothelioma	GDSC	KRAALGRMC	DEG_APCC_DBOX_1	130:138	Mutation altering degron motif	0.6507
p.M137I	ACH-000648	Lung Cancer	CCLE	KRAALGRMC	DEG_APCC_DBOX_1	130:138	Mutation altering degron motif	0.6507
p.M137I	NCI-H28	pleura	COSMIC	KRAALGRMC	DEG_APCC_DBOX_1	130:138	Mutation altering degron motif	0.6507
p.S159F	TCGA-EE-A3AA	SKCM	TCGA	VRQHLSRLP	DEG_APCC_DBOX_1	154:162	Mutation altering degron motif	0.6871
p.E149K	TCGA-FI-A2D0	UCEC	TCGA	VRQHLSRLP	DEG_APCC_DBOX_1	154:162	Mutation rewiring degron network	0.1944
p.R132C	DO227987	COCA	ICGC	KRAALGRMC	DEG_APCC_DBOX_1	130:138	Mutation altering degron motif	0.8301
p.R132C	DO45127	LIRI	ICGC	KRAALGRMC	DEG_APCC_DBOX_1	130:138	Mutation altering degron motif	0.8301
p.R132C	DO37406	SKCM	ICGC	KRAALGRMC	DEG_APCC_DBOX_1	130:138	Mutation altering degron motif	0.8301
p.R132C	DO51301	SKCM	ICGC	KRAALGRMC	DEG_APCC_DBOX_1	130:138	Mutation altering degron motif	0.8301
p.G146V	DO229015	LICA	ICGC	KRAALGRMC	DEG_APCC_DBOX_1	130:138	Mutation rewiring degron network	0.1111
p.G146V	DO229015	LICA	ICGC	VRQHLSRLP	DEG_APCC_DBOX_1	154:162	Mutation rewiring degron network	0.1111
p.L141F	DO231104	LUSC	ICGC	KRAALGRMC	DEG_APCC_DBOX_1	130:138	Mutation rewiring degron network	0.25
p.R132S	DO47509	SKCM	ICGC	KRAALGRMC	DEG_APCC_DBOX_1	130:138	Mutation altering degron motif	0.7427
p.R132L	DO39756	THCA	ICGC	KRAALGRMC	DEG_APCC_DBOX_1	130:138	Mutation altering degron motif	0.8428
p.K142N	SIDM00723	Non-Small Cell Lung Carcinoma	GDSC	KRAALGRMC	DEG_APCC_DBOX_1	130:138	Mutation blocking ubiquitination signal	0.6667
p.A132V	SIDM00680	Colorectal Carcinoma	GDSC	KRAALGRMC	DEG_APCC_DBOX_1	130:138	Mutation altering degron motif	0.5825
p.A132V	ACH-000957	Colon/Colorectal Cancer	CCLE	KRAALGRMC	DEG_APCC_DBOX_1	130:138	Mutation altering degron motif	0.5825
p.A132V	LS-180	large intestine	COSMIC	KRAALGRMC	DEG_APCC_DBOX_1	130:138	Mutation altering degron motif	0.5825
p.V154M	SIDM00516	Melanoma	GDSC	VRQHLSRLP	DEG_APCC_DBOX_1	154:162	Mutation altering degron motif	0.6097
p.V154M	MZ7-mel	skin	COSMIC	VRQHLSRLP	DEG_APCC_DBOX_1	154:162	Mutation altering degron motif	0.6097
p.D121N	SIDM01588	Endometrial Carcinoma	GDSC	KRAALGRMC	DEG_APCC_DBOX_1	130:138	Mutation rewiring degron network	0.0833
p.D121N	ACH-000993	Endometrial/Uterine Cancer	CCLE	KRAALGRMC	DEG_APCC_DBOX_1	130:138	Mutation rewiring degron network	0.0833

Kaplan plot for GTPBP4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GTPBP4

UniProt ID: Q9BZE4

Entrez ID: 23560

Protein name: GTP-binding protein 4 (Chronic renal failure gene protein) (GTP-binding protein NGB) (Nucleolar GTP-binding protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GTPBP4 in