DegronMD

Uniprot ID: Q9BZE4

Source protein: GTP-binding protein 4

Source gene: GTPBP4

Class: DEG_APCC_DBOX_1

Location: 154:162

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7482

ASA_SCORE: 68.5889

COIL: 0.4567

CONS_SCORE: 0.546

DSS_SCORE: 0.268

HELIX: 0.5218

FCONS_SCORE: 1.2131

RIG_SCORE: 0.7941

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E152G	TCGA-2W-A8YY	CESC	TCGA	VRQHLSRLP	DEG_APCC_DBOX_1	0.2778
p.T168I	TCGA-60-2715	LUSC	TCGA	VRQHLSRLP	DEG_APCC_DBOX_1	0.6111
p.R155C	TCGA-BR-4184	STAD	TCGA	VRQHLSRLP	DEG_APCC_DBOX_1	0.8301
p.R155C	SIDM01307	Colorectal Carcinoma	GDSC	VRQHLSRLP	DEG_APCC_DBOX_1	0.8301
p.S159F	TCGA-EE-A3AA	SKCM	TCGA	VRQHLSRLP	DEG_APCC_DBOX_1	0.6871
p.E149K	TCGA-FI-A2D0	UCEC	TCGA	VRQHLSRLP	DEG_APCC_DBOX_1	0.1944
p.G146V	DO229015	LICA	ICGC	VRQHLSRLP	DEG_APCC_DBOX_1	0.1111
p.V154M	SIDM00516	Melanoma	GDSC	VRQHLSRLP	DEG_APCC_DBOX_1	0.6097
p.V154M	MZ7-mel	skin	COSMIC	VRQHLSRLP	DEG_APCC_DBOX_1	0.6097

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BZE4	GTP-binding protein 4	DEG_APCC_DBOX_1	154:162	VRQHLSRLP	APC,CDC20,FZR1	0.7482	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons