DegronMD

Uniprot ID: Q8N4S0

Source protein: Coiled-coil domain-containing protein 82

Source gene: CCDC82

Class: DEG_APCC_DBOX_1

Location: 236:244

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.617

ASA_SCORE: 111.3778

COIL: 0.1322

CONS_SCORE: 0.5705

DSS_SCORE: 0.616

HELIX: 0.8731

FCONS_SCORE: 0.9969

RIG_SCORE: 0.7596

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S247A	TCGA-AA-A010	COAD	TCGA	KREKLQKLK	DEG_APCC_DBOX_1	0.25
p.R252C	TCGA-B5-A1MR	UCEC	TCGA	KREKLQKLK	DEG_APCC_DBOX_1	0.1111
p.R252C	DO41758	UCEC	ICGC	KREKLQKLK	DEG_APCC_DBOX_1	0.1111
p.E229K	TCGA-BH-A1F8	BRCA	TCGA	KREKLQKLK	DEG_APCC_DBOX_1	0.1389
p.E229K	DO1512	BRCA	ICGC	KREKLQKLK	DEG_APCC_DBOX_1	0.1389
p.R252H	TCGA-RD-A7C1	STAD	TCGA	KREKLQKLK	DEG_APCC_DBOX_1	0.1111
p.R252H	DO50132	STAD	ICGC	KREKLQKLK	DEG_APCC_DBOX_1	0.1111
p.Q235K	DO229029	LICA	ICGC	KREKLQKLK	DEG_APCC_DBOX_1	0.3056
p.L246F	DO230934	LUSC	ICGC	KREKLQKLK	DEG_APCC_DBOX_1	0.2778
p.L246F	DO224581	LUSC	ICGC	KREKLQKLK	DEG_APCC_DBOX_1	0.2778
p.A234S	SIDM00852	Glioma	GDSC	KREKLQKLK	DEG_APCC_DBOX_1	0.2778
p.A234S	ACH-000389	Brain Cancer	CCLE	KREKLQKLK	DEG_APCC_DBOX_1	0.2778
p.A234S	H4	central_nervous_system	COSMIC	KREKLQKLK	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N4S0	Coiled-coil domain-containing protein 82	DEG_APCC_DBOX_1	236:244	KREKLQKLK	APC,CDC20,FZR1	0.617	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons