DegronMD - Q8N4S0(CCDC82)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S247A	TCGA-AA-A010	COAD	TCGA	KREKLQKLK	DEG_APCC_DBOX_1	236:244	Mutation rewiring degron network	0.25
p.D176G	TCGA-AM-5821	COAD	TCGA	KRKRLSSVM	DEG_APCC_DBOX_1	181:189	Mutation rewiring degron network	0.1944
p.D176G	DO8240	COAD	ICGC	KRKRLSSVM	DEG_APCC_DBOX_1	181:189	Mutation rewiring degron network	0.1944
p.R252C	TCGA-B5-A1MR	UCEC	TCGA	KREKLQKLK	DEG_APCC_DBOX_1	236:244	Mutation rewiring degron network	0.1111
p.R252C	DO41758	UCEC	ICGC	KREKLQKLK	DEG_APCC_DBOX_1	236:244	Mutation rewiring degron network	0.1111
p.E229K	TCGA-BH-A1F8	BRCA	TCGA	KREKLQKLK	DEG_APCC_DBOX_1	236:244	Mutation rewiring degron network	0.1389
p.E229K	DO1512	BRCA	ICGC	KREKLQKLK	DEG_APCC_DBOX_1	236:244	Mutation rewiring degron network	0.1389
p.R252H	TCGA-RD-A7C1	STAD	TCGA	KREKLQKLK	DEG_APCC_DBOX_1	236:244	Mutation rewiring degron network	0.1111
p.R252H	DO50132	STAD	ICGC	KREKLQKLK	DEG_APCC_DBOX_1	236:244	Mutation rewiring degron network	0.1111
p.S187F	DO50454	ESAD	ICGC	KRKRLSSVM	DEG_APCC_DBOX_1	181:189	Mutation altering degron motif	0.7982
p.Q235K	DO229029	LICA	ICGC	KREKLQKLK	DEG_APCC_DBOX_1	236:244	Mutation rewiring degron network	0.3056
p.D197E	DO229027	LICA	ICGC	KRKRLSSVM	DEG_APCC_DBOX_1	181:189	Mutation rewiring degron network	0.1111
p.D176E	DO229041	LICA	ICGC	KRKRLSSVM	DEG_APCC_DBOX_1	181:189	Mutation rewiring degron network	0.1944
p.S198R	DO229009	LICA	ICGC	KRKRLSSVM	DEG_APCC_DBOX_1	181:189	Mutation blocking phosphorylation signal	0.5278
p.L246F	DO230934	LUSC	ICGC	KREKLQKLK	DEG_APCC_DBOX_1	236:244	Mutation rewiring degron network	0.2778
p.L246F	DO224581	LUSC	ICGC	KREKLQKLK	DEG_APCC_DBOX_1	236:244	Mutation rewiring degron network	0.2778
p.E194D	SIDM00112	Kidney Carcinoma	GDSC	KRKRLSSVM	DEG_APCC_DBOX_1	181:189	Mutation rewiring degron network	0.1944
p.E194D	ACH-000428	Kidney Cancer	CCLE	KRKRLSSVM	DEG_APCC_DBOX_1	181:189	Mutation rewiring degron network	0.1944
p.E194D	U031	kidney	COSMIC	KRKRLSSVM	DEG_APCC_DBOX_1	181:189	Mutation rewiring degron network	0.1944
p.D199N	SIDM00221	Melanoma	GDSC	KRKRLSSVM	DEG_APCC_DBOX_1	181:189	Mutation rewiring degron network	0.0556
p.D199N	ACH-002388	Skin Cancer	CCLE	KRKRLSSVM	DEG_APCC_DBOX_1	181:189	Mutation rewiring degron network	0.0556
p.A234S	SIDM00852	Glioma	GDSC	KREKLQKLK	DEG_APCC_DBOX_1	236:244	Mutation rewiring degron network	0.2778
p.A234S	ACH-000389	Brain Cancer	CCLE	KREKLQKLK	DEG_APCC_DBOX_1	236:244	Mutation rewiring degron network	0.2778
p.A234S	H4	central nervous system	COSMIC	KREKLQKLK	DEG_APCC_DBOX_1	236:244	Mutation rewiring degron network	0.2778
p.E199K	KMOE-2	haematopoietic and lymphoid tissue	COSMIC	KRKRLSSVM	DEG_APCC_DBOX_1	181:189	Mutation rewiring degron network	0.0556
p.D193H	RL	haematopoietic and lymphoid tissue	COSMIC	KRKRLSSVM	DEG_APCC_DBOX_1	181:189	Mutation rewiring degron network	0.2222
p.E171D	U031	kidney	COSMIC	KRKRLSSVM	DEG_APCC_DBOX_1	181:189	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CCDC82

UniProt ID: Q8N4S0

Entrez ID: 79780

Protein name: Coiled-coil domain-containing protein 82

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CCDC82 in