DegronMD

Uniprot ID: Q8N4S0

Source protein: Coiled-coil domain-containing protein 82

Source gene: CCDC82

Class: DEG_APCC_DBOX_1

Location: 181:189

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9848

ASA_SCORE: 119.1333

COIL: 0.8071

CONS_SCORE: 0.5868

DSS_SCORE: 0.4723

HELIX: 0.0973

FCONS_SCORE: 1.1174

RIG_SCORE: 0.7146

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D176G	TCGA-AM-5821	COAD	TCGA	KRKRLSSVM	DEG_APCC_DBOX_1	0.1944
p.D176G	DO8240	COAD	ICGC	KRKRLSSVM	DEG_APCC_DBOX_1	0.1944
p.S187F	DO50454	ESAD	ICGC	KRKRLSSVM	DEG_APCC_DBOX_1	0.7982
p.D197E	DO229027	LICA	ICGC	KRKRLSSVM	DEG_APCC_DBOX_1	0.1111
p.D176E	DO229041	LICA	ICGC	KRKRLSSVM	DEG_APCC_DBOX_1	0.1944
p.S198R	DO229009	LICA	ICGC	KRKRLSSVM	DEG_APCC_DBOX_1	0.5278
p.E194D	SIDM00112	Kidney Carcinoma	GDSC	KRKRLSSVM	DEG_APCC_DBOX_1	0.1944
p.E194D	ACH-000428	Kidney Cancer	CCLE	KRKRLSSVM	DEG_APCC_DBOX_1	0.1944
p.E194D	U031	kidney	COSMIC	KRKRLSSVM	DEG_APCC_DBOX_1	0.1944
p.D199N	SIDM00221	Melanoma	GDSC	KRKRLSSVM	DEG_APCC_DBOX_1	0.0556
p.D199N	ACH-002388	Skin Cancer	CCLE	KRKRLSSVM	DEG_APCC_DBOX_1	0.0556
p.E199K	KMOE-2	haematopoietic_and_lymphoid_tissue	COSMIC	KRKRLSSVM	DEG_APCC_DBOX_1	0.0556
p.D193H	RL	haematopoietic_and_lymphoid_tissue	COSMIC	KRKRLSSVM	DEG_APCC_DBOX_1	0.2222
p.E171D	U031	kidney	COSMIC	KRKRLSSVM	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N4S0	Coiled-coil domain-containing protein 82	DEG_APCC_DBOX_1	181:189	KRKRLSSVM	APC,CDC20,FZR1	0.9848	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons