DegronMD

Uniprot ID: O60610

Source protein: Protein diaphanous homolog 1

Source gene: DIAPH1

Class: DEG_APCC_DBOX_1

Location: 1182:1190

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5396

ASA_SCORE: 115.7222

COIL: 0.4574

CONS_SCORE: 0.3202

DSS_SCORE: 0.5527

HELIX: 0.5158

FCONS_SCORE: 0.8867

RIG_SCORE: 0.7525

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1192A	TCGA-CA-6717	COAD	TCGA	KREQLIDMN	DEG_APCC_DBOX_1	0.2778
p.E1192V	TCGA-DK-AA71	BLCA	TCGA	KREQLIDMN	DEG_APCC_DBOX_1	0.2778
p.D1194N	TCGA-ZJ-AAXT	CESC	TCGA	KREQLIDMN	DEG_APCC_DBOX_1	0.2222
p.Q1183H	DO222769	COCA	ICGC	KREQLIDMN	DEG_APCC_DBOX_1	0.7582
p.S1177N	DO10880	GBM	ICGC	KREQLIDMN	DEG_APCC_DBOX_1	0.1944
p.A1187E	DO229045	LICA	ICGC	KREQLIDMN	DEG_APCC_DBOX_1	0.7701
p.G1193E	DO229054	LICA	ICGC	KREQLIDMN	DEG_APCC_DBOX_1	0.25
p.R1195L	DO219176	LUSC	ICGC	KREQLIDMN	DEG_APCC_DBOX_1	0.1944
p.R1195H	DO46657	PAAD	ICGC	KREQLIDMN	DEG_APCC_DBOX_1	0.1944
p.A1196S	RH-1	soft_tissue	COSMIC	KREQLIDMN	DEG_APCC_DBOX_1	0.1667
p.T1186I	MZ7-mel	skin	COSMIC	KREQLIDMN	DEG_APCC_DBOX_1	0.7078

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60610	Protein diaphanous homolog 1	DEG_APCC_DBOX_1	1182:1190	KREQLIDMN	APC,CDC20,FZR1	0.5396	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons