DegronMD - O60610(DIAPH1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A760S	TCGA-53-7626	LUAD	TCGA	VPAAPVLPF	DEG_SIAH_1	757:765	Mutation altering degron motif	0.7588
p.K770Q	TCGA-BR-8078	STAD	TCGA	VPAAPVLPF	DEG_SIAH_1	757:765	Mutation substituting flanking lysine	0.3056
p.E1192A	TCGA-CA-6717	COAD	TCGA	KREQLIDMN	DEG_APCC_DBOX_1	1182:1190	Mutation rewiring degron network	0.2778
p.G766R	TCGA-D3-A5GU	SKCM	TCGA	VPAAPVLPF	DEG_SIAH_1	757:765	Mutation rewiring degron network	0.3056
p.E1192V	TCGA-DK-AA71	BLCA	TCGA	KREQLIDMN	DEG_APCC_DBOX_1	1182:1190	Mutation rewiring degron network	0.2778
p.P749S	TCGA-GV-A3JZ	BLCA	TCGA	VPAAPVLPF	DEG_SIAH_1	757:765	Mutation rewiring degron network	0.1111
p.D1194N	TCGA-ZJ-AAXT	CESC	TCGA	KREQLIDMN	DEG_APCC_DBOX_1	1182:1190	Mutation rewiring degron network	0.2222
p.Q1183H	DO222769	COCA	ICGC	KREQLIDMN	DEG_APCC_DBOX_1	1182:1190	Mutation altering degron motif	0.7582
p.V767A	DO233791	GACA	ICGC	VPAAPVLPF	DEG_SIAH_1	757:765	Mutation rewiring degron network	0.2778
p.S1177N	DO10880	GBM	ICGC	KREQLIDMN	DEG_APCC_DBOX_1	1182:1190	Mutation rewiring degron network	0.1944
p.L758F	DO15623	HNSC	ICGC	VPAAPVLPF	DEG_SIAH_1	757:765	Mutation altering degron motif	0.6981
p.D770E	DO229019	LICA	ICGC	VPAAPVLPF	DEG_SIAH_1	757:765	Mutation substituting flanking lysine	0.3056
p.A1187E	DO229045	LICA	ICGC	KREQLIDMN	DEG_APCC_DBOX_1	1182:1190	Mutation altering degron motif	0.7701
p.G1193E	DO229054	LICA	ICGC	KREQLIDMN	DEG_APCC_DBOX_1	1182:1190	Mutation rewiring degron network	0.25
p.R1195L	DO219176	LUSC	ICGC	KREQLIDMN	DEG_APCC_DBOX_1	1182:1190	Mutation rewiring degron network	0.1944
p.R1195H	DO46657	PAAD	ICGC	KREQLIDMN	DEG_APCC_DBOX_1	1182:1190	Mutation rewiring degron network	0.1944
p.K749Q	DO38288	STAD	ICGC	VPAAPVLPF	DEG_SIAH_1	757:765	Mutation rewiring degron network	0.1111
p.A768T	DO42312	UCEC	ICGC	VPAAPVLPF	DEG_SIAH_1	757:765	Mutation blocking phosphorylation signal	0.6944
p.L772V	SIDM00845	Burkitt's Lymphoma	GDSC	VPAAPVLPF	DEG_SIAH_1	757:765	Mutation rewiring degron network	0.1389
p.L772V	SIDM00461	Acute Myeloid Leukemia	GDSC	VPAAPVLPF	DEG_SIAH_1	757:765	Mutation rewiring degron network	0.1389
p.A1196S	RH-1	soft tissue	COSMIC	KREQLIDMN	DEG_APCC_DBOX_1	1182:1190	Mutation rewiring degron network	0.1667
p.T1186I	MZ7-mel	skin	COSMIC	KREQLIDMN	DEG_APCC_DBOX_1	1182:1190	Mutation altering degron motif	0.7078
p.Q769R	JAR	placenta	COSMIC	VPAAPVLPF	DEG_SIAH_1	757:765	Mutation rewiring degron network	0.2222

Kaplan plot for DIAPH1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DIAPH1

UniProt ID: O60610

Entrez ID: 1729

Protein name: Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DIAPH1 in