DegronMD

Uniprot ID: O60610

Source protein: Protein diaphanous homolog 1

Source gene: DIAPH1

Class: DEG_SIAH_1

Location: 757:765

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9893

ASA_SCORE: 75.8556

COIL: 0.8959

CONS_SCORE: 0.3159

DSS_SCORE: 0.2951

HELIX: 0.0649

FCONS_SCORE: 0.7122

RIG_SCORE: 0.7268

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A760S	TCGA-53-7626	LUAD	TCGA	VPAAPVLPF	DEG_SIAH_1	0.7588
p.K770Q	TCGA-BR-8078	STAD	TCGA	VPAAPVLPF	DEG_SIAH_1	0.3056
p.G766R	TCGA-D3-A5GU	SKCM	TCGA	VPAAPVLPF	DEG_SIAH_1	0.3056
p.P749S	TCGA-GV-A3JZ	BLCA	TCGA	VPAAPVLPF	DEG_SIAH_1	0.1111
p.V767A	DO233791	GACA	ICGC	VPAAPVLPF	DEG_SIAH_1	0.2778
p.L758F	DO15623	HNSC	ICGC	VPAAPVLPF	DEG_SIAH_1	0.6981
p.D770E	DO229019	LICA	ICGC	VPAAPVLPF	DEG_SIAH_1	0.3056
p.K749Q	DO38288	STAD	ICGC	VPAAPVLPF	DEG_SIAH_1	0.1111
p.A768T	DO42312	UCEC	ICGC	VPAAPVLPF	DEG_SIAH_1	0.6944
p.L772V	SIDM00845	Burkitt's Lymphoma	GDSC	VPAAPVLPF	DEG_SIAH_1	0.1389
p.L772V	SIDM00461	Acute Myeloid Leukemia	GDSC	VPAAPVLPF	DEG_SIAH_1	0.1389
p.Q769R	JAR	placenta	COSMIC	VPAAPVLPF	DEG_SIAH_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60610	Protein diaphanous homolog 1	DEG_SIAH_1	757:765	VPAAPVLPF	SIAH1,SIAH2,SIAH3	0.9893	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons