DegronMD

Uniprot ID: Q9Y261

Source protein: Hepatocyte nuclear factor 3-beta

Source gene: FOXA2

Class: DEG_APCC_DBOX_1

Location: 315:323

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8989

ASA_SCORE: 90.4556

COIL: 0.8518

CONS_SCORE: 0.4507

DSS_SCORE: 0.7381

HELIX: 0.0737

FCONS_SCORE: 1.1182

RIG_SCORE: 0.5713

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G326R	TCGA-EB-A6QY	SKCM	TCGA	KRGGLGELK	DEG_APCC_DBOX_1	0.25
p.G326R	DO48702	SKCM	ICGC	KRGGLGELK	DEG_APCC_DBOX_1	0.25
p.S312W	TCGA-FD-A43X	BLCA	TCGA	KRGGLGELK	DEG_APCC_DBOX_1	0.25
p.S312W	DO44067	BLCA	ICGC	KRGGLGELK	DEG_APCC_DBOX_1	0.25
p.S312W	ACH-001997	Bile Duct Cancer	CCLE	KRGGLGELK	DEG_APCC_DBOX_1	0.25
p.P316L	DO223436	CLLE	ICGC	KRGGLGELK	DEG_APCC_DBOX_1	0.7582
p.C317F	DO222446	ESCA	ICGC	KRGGLGELK	DEG_APCC_DBOX_1	0.7108
p.T331M	DO233002	GACA	ICGC	KRGGLGELK	DEG_APCC_DBOX_1	0.1111
p.G324S	DO220877	MELA	ICGC	KRGGLGELK	DEG_APCC_DBOX_1	0.3056
p.H314R	ACH-000574	Ovarian Cancer	CCLE	KRGGLGELK	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y261	Hepatocyte nuclear factor 3-beta	DEG_APCC_DBOX_1	315:323	KRGGLGELK	APC,CDC20,FZR1	0.8989	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons