DegronMD

Uniprot ID: P00797

Source protein: Renin

Source gene: REN

Class: DEG_APCC_DBOX_1

Location: 32:40

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7498

ASA_SCORE: 61.9444

COIL: 0.2999

CONS_SCORE: 0.5191

DSS_SCORE: 0.2424

HELIX: 0.007

FCONS_SCORE: 1.2604

RIG_SCORE: 0.9102

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R43Q	TCGA-55-A48Y	LUAD	TCGA	KRIFLKRMP	DEG_APCC_DBOX_1	0.25
p.R43Q	TCGA-DA-A1IC	SKCM	TCGA	KRIFLKRMP	DEG_APCC_DBOX_1	0.25
p.R43Q	DO26160	LUAD	ICGC	KRIFLKRMP	DEG_APCC_DBOX_1	0.25
p.R43Q	DO37430	SKCM	ICGC	KRIFLKRMP	DEG_APCC_DBOX_1	0.25
p.R43Q	SIDM00562	Breast Carcinoma	GDSC	KRIFLKRMP	DEG_APCC_DBOX_1	0.25
p.R43Q	ACH-002163	Breast Cancer	CCLE	KRIFLKRMP	DEG_APCC_DBOX_1	0.25
p.R43Q	MRK-nu-1	breast	COSMIC	KRIFLKRMP	DEG_APCC_DBOX_1	0.25
p.T29A	TCGA-EO-A22R	UCEC	TCGA	KRIFLKRMP	DEG_APCC_DBOX_1	0.25
p.T29A	DO42713	UCEC	ICGC	KRIFLKRMP	DEG_APCC_DBOX_1	0.25
p.R49L	TCGA-G2-A2EJ	BLCA	TCGA	KRIFLKRMP	DEG_APCC_DBOX_1	0.0833
p.R49L	DO554	BLCA	ICGC	KRIFLKRMP	DEG_APCC_DBOX_1	0.0833
p.R43P	TCGA-Q1-A5R3	CESC	TCGA	KRIFLKRMP	DEG_APCC_DBOX_1	0.25
p.R43P	DO49008	CESC	ICGC	KRIFLKRMP	DEG_APCC_DBOX_1	0.25
p.E48K	DO27869	ORCA	ICGC	KRIFLKRMP	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P00797	Renin	DEG_APCC_DBOX_1	32:40	KRIFLKRMP	APC,CDC20,FZR1	0.7498	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons