DegronMD

Uniprot ID: Q99969

Source protein: Retinoic acid receptor responder protein 2

Source gene: RARRES2

Class: DEG_APCC_DBOX_1

Location: 95:103

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5953

ASA_SCORE: 52.3222

COIL: 0.2961

CONS_SCORE: 0.9377

DSS_SCORE: 0.1395

HELIX: 0.0239

FCONS_SCORE: 1.2255

RIG_SCORE: 0.8512

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R113W	TCGA-CD-8527	STAD	TCGA	KRKCLACIK	DEG_APCC_DBOX_1	0.0556
p.R113W	DO47739	STAD	ICGC	KRKCLACIK	DEG_APCC_DBOX_1	0.0556
p.C98G	TCGA-CR-6482	HNSC	TCGA	KRKCLACIK	DEG_APCC_DBOX_1	0.6489
p.C98G	DO15943	HNSC	ICGC	KRKCLACIK	DEG_APCC_DBOX_1	0.6489
p.R96G	TCGA-CR-7371	HNSC	TCGA	KRKCLACIK	DEG_APCC_DBOX_1	0.7568
p.R96G	DO15454	HNSC	ICGC	KRKCLACIK	DEG_APCC_DBOX_1	0.7568
p.E86K	TCGA-E7-A7XN	BLCA	TCGA	KRKCLACIK	DEG_APCC_DBOX_1	0.0833
p.E86K	DO51878	BLCA	ICGC	KRKCLACIK	DEG_APCC_DBOX_1	0.0833
p.E86K	SIDM01577	Plasma Cell Myeloma	GDSC	KRKCLACIK	DEG_APCC_DBOX_1	0.0833
p.E86K	ACH-000889	Myeloma	CCLE	KRKCLACIK	DEG_APCC_DBOX_1	0.0833
p.G93R	TCGA-EE-A29M	SKCM	TCGA	KRKCLACIK	DEG_APCC_DBOX_1	0.2778
p.G93R	DO37404	SKCM	ICGC	KRKCLACIK	DEG_APCC_DBOX_1	0.2778
p.C101R	TCGA-FR-A8YC	SKCM	TCGA	KRKCLACIK	DEG_APCC_DBOX_1	0.719
p.C101R	DO50301	SKCM	ICGC	KRKCLACIK	DEG_APCC_DBOX_1	0.719
p.R113Q	TCGA-XK-AAIW	PRAD	TCGA	KRKCLACIK	DEG_APCC_DBOX_1	0.0556
p.R113Q	DO51407	PRAD	ICGC	KRKCLACIK	DEG_APCC_DBOX_1	0.0556
p.G112D	DO231987	LICA	ICGC	KRKCLACIK	DEG_APCC_DBOX_1	0.0833
p.P91T	DO228974	LICA	ICGC	KRKCLACIK	DEG_APCC_DBOX_1	0.2222
p.R96W	DO228138	PBCA	ICGC	KRKCLACIK	DEG_APCC_DBOX_1	0.8634

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99969	Retinoic acid receptor responder protein 2	DEG_APCC_DBOX_1	95:103	KRKCLACIK	APC,CDC20,FZR1	0.5953	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons