DegronMD

Uniprot ID: O95931

Source protein: Chromobox protein homolog 7

Source gene: CBX7

Class: DEG_APCC_DBOX_1

Location: 77:85

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6085

ASA_SCORE: 109.3667

COIL: 0.4059

CONS_SCORE: 0.5465

DSS_SCORE: 0.468

HELIX: 0.4218

FCONS_SCORE: 0.985

RIG_SCORE: 0.8126

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K77R	TCGA-19-1786	GBM	TCGA	KRLLLQRLY	DEG_APCC_DBOX_1	0.6126
p.K77R	DO11956	GBM	ICGC	KRLLLQRLY	DEG_APCC_DBOX_1	0.6126
p.D88E	TCGA-66-2773	LUSC	TCGA	KRLLLQRLY	DEG_APCC_DBOX_1	0.25
p.D88E	DO26536	LUSC	ICGC	KRLLLQRLY	DEG_APCC_DBOX_1	0.25
p.R78W	TCGA-AA-A01R	COAD	TCGA	KRLLLQRLY	DEG_APCC_DBOX_1	0.8634
p.R78W	DO7934	COAD	ICGC	KRLLLQRLY	DEG_APCC_DBOX_1	0.8634
p.R72I	TCGA-D1-A17Q	UCEC	TCGA	KRLLLQRLY	DEG_APCC_DBOX_1	0.1944
p.R72I	DO41903	UCEC	ICGC	KRLLLQRLY	DEG_APCC_DBOX_1	0.1944
p.G68W	TCGA-D9-A149	SKCM	TCGA	KRLLLQRLY	DEG_APCC_DBOX_1	0.0833
p.G68W	DO37420	SKCM	ICGC	KRLLLQRLY	DEG_APCC_DBOX_1	0.0833
p.P74L	TCGA-FI-A2D0	UCEC	TCGA	KRLLLQRLY	DEG_APCC_DBOX_1	0.25
p.P74L	DO43891	UCEC	ICGC	KRLLLQRLY	DEG_APCC_DBOX_1	0.25
p.R78Q	TCGA-FP-A4BE	STAD	TCGA	KRLLLQRLY	DEG_APCC_DBOX_1	0.7329
p.R78Q	DO48016	STAD	ICGC	KRLLLQRLY	DEG_APCC_DBOX_1	0.7329
p.A93S	DO231776	LINC	ICGC	KRLLLQRLY	DEG_APCC_DBOX_1	0.1111
p.R90Q	DO227664	PBCA	ICGC	KRLLLQRLY	DEG_APCC_DBOX_1	0.1944
p.V89I	CCK-81	large_intestine	COSMIC	KRLLLQRLY	DEG_APCC_DBOX_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95931	Chromobox protein homolog 7	DEG_APCC_DBOX_1	77:85	KRLLLQRLY	APC,CDC20,FZR1	0.6085	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons