DegronMD

Uniprot ID: Q86T20

Source protein: Small integral membrane protein 29

Source gene: SMIM29

Class: DEG_APCC_DBOX_1

Location: 93:101

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9668

ASA_SCORE: 93.9222

COIL: 0.7353

CONS_SCORE: 0.6372

DSS_SCORE: 0.6493

HELIX: 0.0858

FCONS_SCORE: 1.2362

RIG_SCORE: 0.7883

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L86P	SIDM00582	Pancreatic Carcinoma	GDSC	KRMPLLDVK	DEG_APCC_DBOX_1	0.1389
p.L86P	SIDM00608	Plasma Cell Myeloma	GDSC	KRMPLLDVK	DEG_APCC_DBOX_1	0.1389
p.L86P	SIDM00548	Squamous Cell Lung Carcinoma	GDSC	KRMPLLDVK	DEG_APCC_DBOX_1	0.1389
p.L86P	SIDM00486	Squamous Cell Lung Carcinoma	GDSC	KRMPLLDVK	DEG_APCC_DBOX_1	0.1389
p.L86P	SIDM00567	Other Solid Cancers	GDSC	KRMPLLDVK	DEG_APCC_DBOX_1	0.1389
p.L86P	SIDM01217	Other Blood Cancers	GDSC	KRMPLLDVK	DEG_APCC_DBOX_1	0.1389
p.L86P	SIDM00579	Neuroblastoma	GDSC	KRMPLLDVK	DEG_APCC_DBOX_1	0.1389
p.L86P	SIDM01612	Endometrial Carcinoma	GDSC	KRMPLLDVK	DEG_APCC_DBOX_1	0.1389
p.L86P	SIDM01617	Endometrial Carcinoma	GDSC	KRMPLLDVK	DEG_APCC_DBOX_1	0.1389
p.L86P	SIDM01335	Kidney Carcinoma	GDSC	KRMPLLDVK	DEG_APCC_DBOX_1	0.1389
p.L86P	SIDM00168	Head and Neck Carcinoma	GDSC	KRMPLLDVK	DEG_APCC_DBOX_1	0.1389
p.L86P	SIDM01770	Gastric Carcinoma	GDSC	KRMPLLDVK	DEG_APCC_DBOX_1	0.1389
p.L86P	SIDM01779	Gastric Carcinoma	GDSC	KRMPLLDVK	DEG_APCC_DBOX_1	0.1389
p.L86P	SIDM01434	Hepatocellular Carcinoma	GDSC	KRMPLLDVK	DEG_APCC_DBOX_1	0.1389
p.C83R	SIDM00400	B-Cell Non-Hodgkin's Lymphoma	GDSC	KRMPLLDVK	DEG_APCC_DBOX_1	0.0556
p.C83R	SIDM00638	Cervical Carcinoma	GDSC	KRMPLLDVK	DEG_APCC_DBOX_1	0.0556
p.P107S	SIDM00068	Colorectal Carcinoma	GDSC	KRMPLLDVK	DEG_APCC_DBOX_1	0.1667
p.P107S	GEO	large_intestine	COSMIC	KRMPLLDVK	DEG_APCC_DBOX_1	0.1667
p.P107A	SIDM01451	Pancreatic Carcinoma	GDSC	KRMPLLDVK	DEG_APCC_DBOX_1	0.1667
p.P87S	GEO	large_intestine	COSMIC	KRMPLLDVK	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86T20	Small integral membrane protein 29	DEG_APCC_DBOX_1	93:101	KRMPLLDVK	APC,CDC20,FZR1	0.9668	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons