DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
KRPRLDPVL
Uniprot ID:
A8MWA6
Source protein:
Putative protein FAM90A22
Source gene:
FAM90A22
Class:
DEG_APCC_DBOX_1
Location:
157:165
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.8169
ASA_SCORE:
100.3556
COIL:
0.82
CONS_SCORE:
0.3609
DSS_SCORE:
0.6115
HELIX:
0.1506
FCONS_SCORE:
0.9837
RIG_SCORE:
0.7257
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with FAM90A22 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of KRPRLDPVL
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A8MWA6
Putative protein FAM90A22
DEG_APCC_DBOX_1
157:165
KRPRLDPVL
APC,CDC20,FZR1
0.8169
More...
A8MXZ1
Putative protein FAM90A23
DEG_APCC_DBOX_1
157:165
KRPRLDPVL
APC,CDC20,FZR1
0.9141
More...
P0C7V4
Putative protein FAM90A15P
DEG_APCC_DBOX_1
157:165
KRPRLDPVL
APC,CDC20,FZR1
0.8101
More...
P0C7W8
Putative protein FAM90A13P
DEG_APCC_DBOX_1
157:165
KRPRLDPVL
APC,CDC20,FZR1
0.8437
More...
P0C7W9
Putative protein FAM90A14
DEG_APCC_DBOX_1
157:165
KRPRLDPVL
APC,CDC20,FZR1
0.8726
More...
P0C7X0
Putative protein FAM90A24P
DEG_APCC_DBOX_1
157:165
KRPRLDPVL
APC,CDC20,FZR1
0.8726
More...