DegronMD

Uniprot ID: Q8TBE0

Source protein: Bromo adjacent homology domain-containing 1 protein

Source gene: BAHD1

Class: DEG_APCC_DBOX_1

Location: 169:177

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.952

ASA_SCORE: 97.7778

COIL: 0.8997

CONS_SCORE: 0.3571

DSS_SCORE: 0.7352

HELIX: 0.0374

FCONS_SCORE: 1.0369

RIG_SCORE: 0.5744

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R172W	TCGA-2W-A8YY	CESC	TCGA	KRPRLGDLG	DEG_APCC_DBOX_1	0.7523
p.R172W	DO223732	CESC	ICGC	KRPRLGDLG	DEG_APCC_DBOX_1	0.7523
p.P187S	TCGA-AP-A059	UCEC	TCGA	KRPRLGDLG	DEG_APCC_DBOX_1	0.0556
p.P187S	DO41361	UCEC	ICGC	KRPRLGDLG	DEG_APCC_DBOX_1	0.0556
p.G163D	TCGA-BH-A0HF	BRCA	TCGA	KRPRLGDLG	DEG_APCC_DBOX_1	0.1667
p.G163D	DO1749	BRCA	ICGC	KRPRLGDLG	DEG_APCC_DBOX_1	0.1667
p.R170W	TCGA-D7-8570	STAD	TCGA	KRPRLGDLG	DEG_APCC_DBOX_1	0.8634
p.R170W	DO48040	STAD	ICGC	KRPRLGDLG	DEG_APCC_DBOX_1	0.8634
p.S184Y	TCGA-EO-A22R	UCEC	TCGA	KRPRLGDLG	DEG_APCC_DBOX_1	0.5833
p.S184Y	DO42713	UCEC	ICGC	KRPRLGDLG	DEG_APCC_DBOX_1	0.5833
p.A160D	TCGA-GL-A4EM	KIRP	TCGA	KRPRLGDLG	DEG_APCC_DBOX_1	0.0833
p.A160D	DO44520	KIRP	ICGC	KRPRLGDLG	DEG_APCC_DBOX_1	0.0833
p.K168N	DO229221	THCA	ICGC	KRPRLGDLG	DEG_APCC_DBOX_1	0.3056
p.D175H	SIDM00003	Melanoma	GDSC	KRPRLGDLG	DEG_APCC_DBOX_1	0.6577
p.D175H	ACH-000884	Skin Cancer	CCLE	KRPRLGDLG	DEG_APCC_DBOX_1	0.6577
p.D175H	ACH-002159	Skin Cancer	CCLE	KRPRLGDLG	DEG_APCC_DBOX_1	0.6577
p.D175H	M14	skin	COSMIC	KRPRLGDLG	DEG_APCC_DBOX_1	0.6577
p.R170Q	SIDM00887	Other Solid Cancers	GDSC	KRPRLGDLG	DEG_APCC_DBOX_1	0.7329
p.R170Q	Daoy	central_nervous_system	COSMIC	KRPRLGDLG	DEG_APCC_DBOX_1	0.7329

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TBE0	Bromo adjacent homology domain-containing 1 protein	DEG_APCC_DBOX_1	169:177	KRPRLGDLG	APC,CDC20,FZR1	0.952	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons